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Relationship between screening plasma glucose concentrations and cancer- and all-cause mortality: the Jichi Medical School (JMS) cohort study

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Abstract

Aim

Whether plasma glucose concentrations at the screening level in the public health care setting can predict mortality remains to be determined in Japanese people. The aim of this study was to investigate the relationships between screening plasma glucose concentrations and cause- and all-cause mortality in a general Japanese cohort.

Subjects and methods

The current study investigated 11,998 community-dwelling participants from 12 Japanese communities who had been registered in the Jichi Medical School Cohort Study (a population-based prospective cohort study) between 1992 and 1995. Mortality was documented as the primary outcome. The relationships between screening plasma glucose concentrations and outcomes were analyzed using Cox proportional hazard models.

Results

In all, 1,050 deaths (men/women = 631/419) were identified during a follow-up period of 10.7 years. Compared with the lowest glucose concentration (<5.22 mmol/L), multivariate-adjusted hazard ratios for the highest glucose concentration (≥6.11 mmol/L) were 1.52 (95 % confidence interval [CI], 1.25–1.85) for all-cause mortality and 1.76 (95 % CI, 1.29–2.41) for cancer-cause mortality in men and 4.65 (95 % CI, 1.69–12.78) for myocardial infarction mortality in women.

Conclusions

The current Japanese population-based cohort study suggests that high screening plasma glucose concentrations can predict cancer- and all-cause mortality, particularly in men.

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References

  • Abe R, Yamagishi S (2008) AGE-RAGE system and carcinogenesis. Curr Pharm Des 14:940–945

    Article  CAS  PubMed  Google Scholar 

  • American Diabetes Association (2004) Screening for type 2 diabetes. Diabetes Care 27:S11–S14

    Article  Google Scholar 

  • Borch-Johnsen K, Lauritzen T, Glümer C, Sandbaek A (2003) Screening for Type 2 diabetes: should it be now? Diabet Med 20:175–181

    Article  CAS  PubMed  Google Scholar 

  • Campbell PT, Newton CC, Patel AV, Jacobs EJ, Gapstur SM (2012) Diabetes and cause-specific mortality in a prospective cohort of one million U.S. adults. Diabetes Care 35:1835–1844

    Article  PubMed Central  PubMed  Google Scholar 

  • Ealovega MW, Tabaei BP, Brandle M, Burke R, Herman WH (2004) Opportunistic screening for diabetes in routine clinical practice. Diabetes Care 27:9–12

    Article  PubMed  Google Scholar 

  • Emerging Risk Factors Collaboration, Seshasai SR, Kaptoge S, Thompson A, Di Angelantonio E, Gao P, Sarwar N, Whincup PH, Mukamal KJ, Gillum RF, Holme I, Njølstad I, Fletcher A, Nilsson P, Lewington S, Collins R, Gudnason V, Thompson SG, Sattar N, Selvin E, Hu FB, Danesh J (2011) Diabetes mellitus, fasting glucose, and risk of cause-specific death. N Engl J Med 364:829–841

    Article  CAS  PubMed  Google Scholar 

  • Fisman EZ, Motro M, Tenenbaum A, Boyko V, Mandelzweig L, Behar S (2001) Impaired fasting glucose concentrations in nondiabetic patients with ischemic heart disease: a marker for a worse prognosis. Am Heart J 141:485–490

    Article  CAS  PubMed  Google Scholar 

  • Fodor JG, Tzerovska R (2004) Coronary heart disease: is gender important? J Mens Health Gend 1:32

    Article  Google Scholar 

  • Folli F, Corradi D, Fanti P, Davalli A, Paez A, Giaccari A, Perego C, Muscogiuri G (2011) The role of oxidative stress in the pathogenesis of type 2 diabetes mellitus micro- and macrovascular complications: avenues for a mechanistic-based therapeutic approach. Curr Diabetes Rev 5:313–324

    Article  Google Scholar 

  • Giovannucci E, Harlan DM, Archer MC, Bergenstal RM, Gapstur SM, Habel LA, Pollak M, Regensteiner JG, Yee D (2010) Diabetes and cancer: a consensus report. Diabetes Care 33:1674–1685

    Article  PubMed Central  PubMed  Google Scholar 

  • Gregg EW, Cheng YJ, Saydah S, Cowie C, Garfield S, Geiss L, Barker L (2012) Trends in death rates among U.S. adults with and without diabetes between 1997 and 2006: findings from the National Health Interview Survey. Diabetes Care 35:1252–1257

    Article  PubMed Central  PubMed  Google Scholar 

  • Guariguata L, Whiting DR, Hambleton I, Beagley J, Linnenkamp U, Shaw JE (2014) Global estimates of diabetes prevalence for 2013 and projections for 2035. Diabetes Res Clin Pract 103:134–149

    Google Scholar 

  • Haffner SM, Lehto S, Rönnemaa T, Pyörälä K, Laakso M (1998) Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction. N Engl J Med 339:229–234

    Article  CAS  PubMed  Google Scholar 

  • International Diabetes Federation (2013) Diabetes atlas sixth edition. IDF, Brussels, Belgium

  • Ishikawa S, Gotoh T, Nago N, Kayaba K (2002) Jichi medical school (JMS) cohort study group. J Epidemiol 12:408–417

    Article  PubMed  Google Scholar 

  • Janssen PG, Gorter KJ, Stolk RP, Rutten GE (2007) Low yield of population-based screening for Type 2 diabetes in the Netherlands: the ADDITION Netherlands study. Fam Pract 24:555–561

    Article  CAS  PubMed  Google Scholar 

  • Jee SH, Ohrr H, Sull JW, Yun JE, Ji M, Samet JM (2005) Fasting serum glucose level and cancer risk in Korean men and women. JAMA 293:194–202

    Article  CAS  PubMed  Google Scholar 

  • Kadowaki S, Okamura T, Hozawa A, Kadowaki T, Kadota A, Murakami Y, Nakamura K, Saitoh S, Nakamura Y, Hayakawa T, Kita Y, Okayama A, Ueshima H, Research Group NIPPONDATA (2008) Relationship of elevated casual blood glucose level with coronary heart disease, cardiovascular disease and all-cause mortality in a representative sample of the Japanese population. NIPPON DATA80. Diabetologia 51:575–582

    Article  CAS  PubMed  Google Scholar 

  • Katanoda K, Matsuda T, Matsuda A, Shibata A, Nishino Y, Fujita M, Soda M, Ioka A, Sobue T, Nishimoto H (2013) An updated report of the trends in cancer incidence and mortality in Japan. Jpn J Clin Oncol 43:492–507

    Article  PubMed  Google Scholar 

  • Leys D, Deplanque D, Mounier-Vehier C, Mackowiak-Cordoliani MA, Lucas C, Bordet R (2002) Stroke prevention: management of modifiable vascular risk factors. J Neurol 249:507–517

    Article  PubMed  Google Scholar 

  • Manuel DG, Schultz SE (2004) Health-related quality of life and health-adjusted life expectancy of people with diabetes in Ontario, Canada, 1996–1997. Diabetes Care 27:407–414

    Article  PubMed  Google Scholar 

  • Murray CJ, Lopez AD (2013) Measuring the global burden of disease. N Engl J Med 369:448–457

    Article  CAS  PubMed  Google Scholar 

  • Nucci LB, Toscano CM, Maia AL, Fonseca CD, Britto MM, Duncan BB, Schmidt MI, Brazilian National Campaign for Diabetes Mellitus Detection Working Group (2004) A nationwide population screening program for diabetes in Brazil. Rev Panam Salud Publica 16:320–327

    Article  PubMed  Google Scholar 

  • Pandey A, Forte V, Abdallah M, Alickaj A, Mahmud S, Asad S, McFarlane SI (2011) Diabetes mellitus and the risk of cancer. Minerva Endocrinol 36:187–209

    CAS  PubMed  Google Scholar 

  • Patel A, Barzi F, Jamrozik K, Lam TH, Ueshima H, Whitlock G, Woodward M, Asia Pacific Cohort Studies Collaboration (2004) Serum triglycerides as a risk factor for cardiovascular diseases in the Asia-Pacific region. Circulation 110:2678–2686

    Article  CAS  PubMed  Google Scholar 

  • Pinkhasov RM, Shteynshlyuger A, Hakimian P, Lindsay GK, Samadi DB, Shabsigh R (2010) Are men shortchanged on health? Perspective on life expectancy, morbidity, and mortality in men and women in the United States. Int J Clin Pract 64:465–474

    Article  CAS  PubMed  Google Scholar 

  • Port SC, Goodarzi MO, Boyle NG, Jennrich RI (2005) Blood glucose: a strong risk factor for mortality in nondiabetic patients with cardiovascular disease. Am Heart J 150:209–214

    Article  CAS  PubMed  Google Scholar 

  • Saaristo T, Moilanen L, Jokelainen J, Korpi-Hyövälti E, Vanhala M, Saltevo J, Niskanen L, Peltonen M, Oksa H, Cederberg H, Tuomilehto J, Uusitupa M, Keinänen-Kiukaanniemi S (2010) Cardiometabolic profile of people screened for high risk of type 2 diabetes in a national diabetes prevention programme (FIN-D2D). Prim Care Diabetes 4:231–239

    Article  PubMed  Google Scholar 

  • Saydah SH, Loria CM, Eberhardt MS, Brancati FL (2003) Abnormal glucose tolerance and the risk of cancer death in the United States. Am J Epidemiol 157:1092–1100

    Article  PubMed  Google Scholar 

  • Takahara M, Katakami N, Kaneto H, Noguchi M, Shimomura I (2013) Evaluation of hypertriglyceridemia using non-fasting health checkup data in a Japanese population. J Atheroscler Thromb 20:661–669

    Article  PubMed  Google Scholar 

  • Thomas MC, Hardoon SL, Papacosta AO, Morris RW, Wannamethee SG, Sloggett A, Whincup PH (2009) Evidence of an accelerating increase in prevalence of diagnosed Type 2 diabetes in British men, 1978–2005. Diabet Med 26:766–772

    Article  CAS  PubMed  Google Scholar 

  • van den Donk M, Sandbaek A, Borch-Johnsen K, Lauritzen T, Simmons RK, Wareham NJ, Griffin SJ, Davies MJ, Khunti K, Rutten GE (2011) Screening for type 2 diabetes. Lessons from the ADDITION-Europe study. Diabet Med 28:1416–1424

    Article  PubMed  Google Scholar 

  • Ziemer DC, Kolm P, Foster JK, Weintraub WS, Vaccarino V, Rhee MK, Varughese RM, Tsui CW, Koch DD, Twombly JG, Narayan KM, Phillips LS (2008) Random plasma glucose in serendipitous screening for glucose intolerance: screening for impaired glucose tolerance study 2. J Gen Intern Med 23:528–535

    Article  PubMed Central  PubMed  Google Scholar 

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Acknowledgements

This work was supported by grants from the Foundation for the Development of the Community, Tochigi, Japan, and the Japan Health and Research Institute, Tokyo, Japan. We are grateful for the co-operation of all the staff involved in the study.

Conflict of interest

The authors have no conflicts of interest to declare.

Author information

Authors and Affiliations

  1. Center for Community Medicine, Jichi Medical University, 3,311-1 Yakushiji, Shimotuke, Tochigi, Japan

    Eiichi Kakehi, Kazuhiko Kotani, Shizukiyo Ishikawa, Yosikazu Nakamura & Eiji Kajii

  2. Wara National Health Insurance Clinic, Gifu, Japan

    Tadao Gotoh

  3. School of Health and Social Services, Saitama Prefectural University, Saitama, Japan

    Kazunori Kayaba

Authors
  1. Eiichi Kakehi
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  2. Kazuhiko Kotani
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  3. Shizukiyo Ishikawa
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  4. Tadao Gotoh
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  5. Kazunori Kayaba
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  6. Yosikazu Nakamura
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  7. Eiji Kajii
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Corresponding author

Correspondence to Shizukiyo Ishikawa.

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Kakehi, E., Kotani, K., Ishikawa, S. et al. Relationship between screening plasma glucose concentrations and cancer- and all-cause mortality: the Jichi Medical School (JMS) cohort study. J Public Health 22, 505–511 (2014). https://doi.org/10.1007/s10389-014-0643-6

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  • DOI: https://doi.org/10.1007/s10389-014-0643-6

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