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Changes in chorioretinal blood flow velocity and cerebral blood flow after carotid endarterectomy

  • Clinical Investigation
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Japanese Journal of Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To investigate the changes in chorioretinal blood flow velocity and cerebral blood after carotid endarterectomy (CEA).

Methods

Nine patients with moderate to severe internal carotid artery stenosis underwent CEA. Chorioretinal blood flow velocity was measured by laser speckle flowgraphy (LSFG), while cerebral blood flow (CBF) was measured by single-photon emission computed tomography (SPECT), on the affected side both before and after CEA. LSFG was evaluated in five areas to determine mean blur rate, while CBF was calculated from regional CBF and cerebrovascular reactivity (CVR), at the middle cerebral artery (MCA) region of each patient.

Results

Five cases showed an increase (mean 3.49 %, range −29.82 to 35.59 %) of average chorioretinal blood flow velocity using LSFG after CEA. A particularly averaged increase in chorioretinal blood flow was observed in the macular area compared with other areas. Similarly, there was an increase in CBF at rest (mean 11.46 %, range −14.51 to 74.14 %) observed using SPECT after surgery. Improvement of CVR was confirmed in four cases. All general and visual symptoms disappeared after CEA. Severe adverse effects, including hyperperfusion syndrome, were not observed in any cases.

Conclusions

LSFG may be useful for the analysis of chorioretinal blood flow changes after CEA.

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Acknowledgments

We thank Masatou Kawashima, M.D. (Department of Neurosurgery, Saga University, Saga, Japan), and Sei Haga, M.D. (Department of Neurosurgery, Kyushu Rosai Hospital, Fukuoka, Japan), for advice on SPECT. This work was supported in part by a grant from the Japan Medical Association and by grant-in-aid #15K10897 for Scientific Research from the Japanese Ministry of Education, Culture, Sports, Science and Technology.

Conflicts of interest

H. Enaida, None; S. Nagata, None; A. Takeda, None; S. Nakao, None; Y. Ikeda, None; T. Ishibashi, None.

Author information

Authors and Affiliations

  1. Department of Ophthalmology, Faculty of Medicine, Saga University, Saga, 849-8501, Japan

    Hiroshi Enaida

  2. Department of Neurosurgery, Clinical Research Center, National Hospital Organization, Kyushu Medical Center, 1-8-1 Jigyohama, Chuo-ku, Fukuoka, 810-8563, Japan

    Shinji Nagata

  3. Department of Ophthalmology, Clinical Research Center, National Hospital Organization, Kyushu Medical Center, 1-8-1 Jigyohama, Chuo-ku, Fukuoka, 810-8563, Japan

    Atsunobu Takeda

  4. Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812-8582, Japan

    Shintaro Nakao, Yasuhiro Ikeda & Tatsuro Ishibashi

Authors
  1. Hiroshi Enaida
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  2. Shinji Nagata
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  3. Atsunobu Takeda
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  4. Shintaro Nakao
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  5. Yasuhiro Ikeda
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  6. Tatsuro Ishibashi
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Corresponding author

Correspondence to Hiroshi Enaida.

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Enaida, H., Nagata, S., Takeda, A. et al. Changes in chorioretinal blood flow velocity and cerebral blood flow after carotid endarterectomy. Jpn J Ophthalmol 60, 459–465 (2016). https://doi.org/10.1007/s10384-016-0472-y

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  • DOI: https://doi.org/10.1007/s10384-016-0472-y

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