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Effectiveness of timely intraoperative iodine irrigation during cataract surgery

  • Clinical Investigation
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Japanese Journal of Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To determine the antiseptic efficacy of timely intraoperative iodine irrigation during cataract surgery.

Methods

A total of 198 eyes of 99 cataract surgery patients were studied. The eyes were randomly assigned to treatment with or without timely intraoperative iodine irrigation of the surgical field with an iodine compound equivalent to 0.33 % povidone-iodine. In eyes in the timely intraoperative iodine irrigation group, the ocular surface was irrigated twice intraoperatively—before the initial incision and before insertion of the intraocular lens (IOL). The efficacy of the antiseptic treatment was evaluated by culture tests using scrapings of the surface of the sclerocornea and conjunctiva to the left of the incision and by broad-range real-time PCR for bacterial 16S ribosomal DNA using scrapings from the right side of the incision.

Results

Following intraoperative application of the iodine, bacteria were not detected in cultures of the samples. For the control eyes without timely iodine irrigation, cultures of samples from five and two eyes were positive before the initial incision and before IOL insertion, respectively. The bacterial DNA copy number before the initial incision was 1.7 ± 0.5 × 103, which was significantly lower than that of the control eyes (1.7 ± 0.6 × 104). For both groups of eyes, the bacterial DNA copy number was significantly lower before the IOL insertion depending on the time course. When the antiseptic effect of the iodine irrigation and time course on bacterial DNA copy number was analyzed using generalized mixed linear regression, both were found to be significantly effective. No significant intraoperative epithelial defect was observed. The postoperative corneal endothelial cell count did not differ significantly between the two groups of eyes.

Conclusions

Timely iodine irrigation can serve as a simple and useful adjunctive disinfection step in cataract surgery.

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Acknowledgments

This work was supported by a Grand-in-Aid for Scientific Research (No. 15K20261) from the Japanese Ministry of Education, Science, and Culture.

Conflicts of interest

K. Matsuura, Grant (Nihon Tenganyaku Kenkyusyo Co.Ltd.); D. Miyazaki, None; S. Sasaki, None; K. Yakura, None; Y. Inoue, Grant (Nihon Tenganyaku Kenkyusyo Co.Ltd.); M. Sakamoto, None.

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Authors and Affiliations

  1. Nojima Hospital, 2714-1 Sesaki-machi, Kurayoshi, Tottori, 682-0863, Japan

    Kazuki Matsuura

  2. Tottori University, 36-1 Nishi-cho, Yonago, Tottori, 683-8504, Japan

    Dai Miyazaki, Shin-ichi Sasaki, Keiko Yakura & Yoshitsugu Inoue

  3. The Research Foundation for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka, 565-0871, Japan

    Masako Sakamoto

Authors
  1. Kazuki Matsuura
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  2. Dai Miyazaki
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  3. Shin-ichi Sasaki
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  4. Keiko Yakura
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  5. Yoshitsugu Inoue
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  6. Masako Sakamoto
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Corresponding author

Correspondence to Kazuki Matsuura.

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Matsuura, K., Miyazaki, D., Sasaki, Si. et al. Effectiveness of timely intraoperative iodine irrigation during cataract surgery. Jpn J Ophthalmol 60, 433–438 (2016). https://doi.org/10.1007/s10384-016-0471-z

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  • DOI: https://doi.org/10.1007/s10384-016-0471-z

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