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Measurement reproducibility of magnetic resonance imaging-based finite element analysis of proximal femur microarchitecture for in vivo assessment of bone strength

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Abstract

Introduction

Osteoporosis is a disease of weak bone. Our goal was to determine the measurement reproducibility of magnetic resonance assessment of proximal femur strength.

Methods

This study had institutional review board approval, and written informed consent was obtained from all subjects. We obtained images of proximal femur microarchitecture by scanning 12 subjects three times within 1 week at 3T using a high-resolution 3-D FLASH sequence. We applied finite element analysis to compute proximal femur stiffness and femoral neck elastic modulus.

Results

Within-day and between-day root-mean-square coefficients of variation and intraclass correlation coefficients ranged from 3.5 to 6.6 % and 0.96 to 0.98, respectively.

Conclusion

The measurement reproducibility of magnetic resonance assessment of proximal femur strength is suitable for clinical studies of disease progression or treatment response related to osteoporosis bone-strengthening interventions.

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References

  1. Kanis JA (2002) Diagnosis of osteoporosis and assessment of fracture risk. Lancet 359:1929–1936

    Article  PubMed  Google Scholar 

  2. Burge R, Dawson-Hughes B, Solomon DH, Wong JB, King A, Tosteson A (2007) Incidence and economic burden of osteoporosis-related fractures in the United States, 2005–2025. J Bone Miner Res 22:465–475

    Article  PubMed  Google Scholar 

  3. Schuit SC, van der Klift M, Weel AE et al (2004) Fracture incidence and association with bone mineral density in elderly men and women: the Rotterdam Study. Bone 34:195–202

    Article  CAS  PubMed  Google Scholar 

  4. Majumdar S (2002) Magnetic resonance imaging of trabecular bone structure. Top Magn Reson Imaging 13:323–334

    Article  PubMed  Google Scholar 

  5. Wehrli FW (2007) Structural and functional assessment of trabecular and cortical bone by micro magnetic resonance imaging. J Magn Reson Imaging 25:390–409

    Article  PubMed  Google Scholar 

  6. Rajapakse CS, Leonard MB, Bhagat YA, Sun W, Magland JF, Wehrli FW (2012) Micro–MR imaging–based computational biomechanics demonstrates reduction in cortical and trabecular bone strength after renal transplantation. Radiology 262:921–931

    Article  Google Scholar 

  7. Han M, Chiba K, Banerjee S, Carballido-Gamio J, Krug R (2014) Variable flip angle three-dimensional fast spin-echo sequence combined with outer volume suppression for imaging trabecular bone structure of the proximal femur. J Magn Reson Imaging. doi:10.1002/jmri.24673

    PubMed Central  Google Scholar 

  8. Chang G, Deniz CM, Honig S et al (2014) Feasibility of three-dimensional MRI of proximal femur microarchitecture at 3 tesla using 26 receive elements without and with parallel imaging. J Magn Reson Imaging 40:229–238

    Article  PubMed Central  PubMed  Google Scholar 

  9. Chang G, Honig S, Brown R et al (2014) Finite element analysis applied to 3-T MR imaging of proximal femur microarchitecture: lower bone strength in patients with fragility fractures compared with control subjects. Radiology 272:464–474

    Article  PubMed Central  PubMed  Google Scholar 

  10. Greenspan SL, Myers ER, Maitland LA, Resnick NM, Hayes WC (1994) Fall severity and bone mineral density as risk factors for hip fracture in ambulatory elderly. JAMA 271:128–133

    Article  CAS  PubMed  Google Scholar 

  11. Keyak JH, Kaneko TS, Tehranzadeh J, Skinner HB (2005) Predicting proximal femoral strength using structural engineering models. Clin Orthop Relat Res 437:219–228

    Article  PubMed  Google Scholar 

  12. Seeman E (2007) Is a change in bone mineral density a sensitive and specific surrogate of anti-fracture efficacy? Bone 41:308–317

    Article  CAS  PubMed  Google Scholar 

  13. Lam SC, Wald MJ, Rajapakse CS, Liu Y, Saha PK, Wehrli FW (2011) Performance of the MRI-based virtual bone biopsy in the distal radius: serial reproducibility and reliability of structural and mechanical parameters in women representative of osteoporosis study populations. Bone 49:895–903

    Article  PubMed Central  PubMed  Google Scholar 

  14. Bhagat YA, Rajapakse CS, Magland JF et al (2011) Performance of μMRI-based virtual bone biopsy for structural and mechanical analysis at the distal tibia at 7T field strength. J Magn Reson Imaging 33:372–381

    Article  PubMed Central  PubMed  Google Scholar 

  15. Carballido-Gamio J, Folkesson J, Karampinos DC et al (2011) Generation of an atlas of the proximal femur and its application to trabecular bone analysis. Magn Reson Med 66:1181–1191

    Article  PubMed Central  PubMed  Google Scholar 

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Acknowledgments

This study was supported by United States National Institutes of Health K23 AR059748 (G.C.), RO1 AR066008 (G.C.), and K25 AR060283 (C.R.).

Conflict of interest

The authors declare that they have no conflicts of interest.

Ethical standards

This study had institutional review board approval and written informed consent was obtained from all subjects. Specifically, it was performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments. All data were de-identified and this manuscript does not contain patient data.

Author information

Authors and Affiliations

  1. Department of Radiology, Center for Biomedical Imaging, NYU Langone Medical Center, 660 First Avenue, Room 334, 3rd Floor, New York, NY, 10016, USA

    Gregory Chang

  2. Department of Radiology, Center for Biomedical Imaging, NYU Langone Medical Center, 660 First Avenue, 4th Floor, New York, NY, 10016, USA

    Gregory Chang, Alexandra Hotca-Cho, Henry Rusinek, Artem Mikheev & Ravinder R. Regatte

  3. Osteoporosis Center, Hospital for Joint Diseases, NYU Langone Medical Center, 301 E. 17th Street, Suite 1101, New York, NY, 10003, USA

    Stephen Honig

  4. Department of Orthopaedic Surgery, Hospital for Joint Diseases, NYU Langone Medical Center, 301 E. 17th Street, 14th Floor, New York, NY, 10003, USA

    Kenneth Egol

  5. Department of Radiology, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA

    Chamith S. Rajapakse

Authors
  1. Gregory Chang
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  2. Alexandra Hotca-Cho
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  3. Henry Rusinek
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  4. Stephen Honig
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  5. Artem Mikheev
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  6. Kenneth Egol
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  7. Ravinder R. Regatte
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  8. Chamith S. Rajapakse
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Corresponding author

Correspondence to Gregory Chang.

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Chang, G., Hotca-Cho, A., Rusinek, H. et al. Measurement reproducibility of magnetic resonance imaging-based finite element analysis of proximal femur microarchitecture for in vivo assessment of bone strength. Magn Reson Mater Phy 28, 407–412 (2015). https://doi.org/10.1007/s10334-014-0475-y

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  • DOI: https://doi.org/10.1007/s10334-014-0475-y

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