Reproducibility and consistency of evaluation techniques for HARDI data
- Kamil GorczewskiAffiliated withSection for Experimental MR in CNS, Department of Neuroradiology, University Hospital Tuebingen Email author
- , Sarah MangAffiliated withSection for Experimental MR in CNS, Department of Neuroradiology, University Hospital Tuebingen
- , Uwe KloseAffiliated withSection for Experimental MR in CNS, Department of Neuroradiology, University Hospital Tuebingen
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
The reproducibility of three evaluation techniques for high angular resolution diffusion imaging (HARDI) data, the diffusion tensor model, q-ball reconstruction and spherical deconvolution, are compared.
Materials and methods
Two healthy volunteers were measured in a 3 T MR system six times with the same measurement parameters; one subject was measured with different b-values. The data was evaluated to compare the consistency and reproducibility of reconstructed diffusion directions and anisotropy values for the three investigated diffusion evaluation techniques. The angle difference between the reconstructed main directions of diffusion for the investigated techniques was evaluated. For q-ball and spherical deconvolution the consistency of the second dominant diffusion direction was additionally examined.
The differences between the tensor model and q-ball or spherical deconvolution in the estimated diffusion direction decrease with an increase in fractional anisotropy. Increasing the smoothing kernel in q-ball reconstruction renders the results similar to the ones from the diffusion tensor evaluation. Consistency in the reconstructed directions did increase for larger b-values.
The evaluation of HARDI data in clinical conditions with q-ball or spherical deconvolution shows consistency and reproducibility similar to the diffusion tensor model, but provides valuable additional information about a second dominant direction of diffusion.
KeywordsQ-ball imaging Spherical deconvolution Tensor model Diffusion Diffusion tensor imaging
- Reproducibility and consistency of evaluation techniques for HARDI data
Magnetic Resonance Materials in Physics, Biology and Medicine
- Online Date
- September 2008
- Print ISSN
- Online ISSN
- Additional Links
- Q-ball imaging
- Spherical deconvolution
- Tensor model
- Diffusion tensor imaging
- Industry Sectors