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Anti-inflammatory and analgesic activities of ethanolic extract of Fumaria capreolata

Activités anti-inflammatoire et analgésique de l’extrait éthanolique de Fumaria capreolata

  • Pharmacognosie
  • Published:
Phytothérapie

Abstract

Fumaria capreolata is used in traditional medicine for its gastrointestinal, hepatoprotective, and antiinflammatory activities. The aim of the present study was to investigate the anti-inflammatory and the analgesic effects of the ethanolic extract of Fumaria capreolata (EFC) in mice. Anti-inflammatory activity was evaluated by using the xylene-induced ear edema and multi-application of TPA induced chronic inflammation, whereas acetic acid-induced abdominal constrictions and formalin-induced licking and biting were used to determine antinociceptive effects. The crud extract of Fumaria capreolata (500 and 250 mg/kg) produced a significant inhibition of ear edema in two models of acute and chronic inflammation, and produced a significant reduction of the number of writhes. Also, in the formalin test, EFC reduced both neurogenic and inflammatory phases. These findings suggest the aerial parts of Fumaria capreolata exhibits potent anti-inflammatory and analgesic activities on chemical behavioral models of nociception and inflammation in mice.

Résumé

Fumaria capreolata est utilisée en médecine traditionnelle pour traiter les maladies inflammatoires et les affections gastro-intestinales. Dans cette étude, nous nous sommes penchés sur les possibles effets anti-inflammatoire et analgésique de l’extrait éthanolique de Fumaria capreolata (EFC) chez les souris. L’activité anti-inflammatoire a été déterminée par d’inhibition de l’oedème causé par le xylène et la multi-application de TPA. Cependant les tests de l’inhibition de la douleur provoquée par l’acide acétique et le formaldéhyde ont été utilisés pour évaluer l’action analgésique d’EFC. L’extrait éthanolique de Fumaria capreolata (500 et 250 mg/kg) a démontré une inhibition significative de l’oedème dans les deux modèles de l’inflammation aiguë et chronique. Les résultats ont montré que Fumaria capreolata a produit une réduction significative du nombre de crampes et la douleur causée par l’injection du formaldéhyde via l’inhibition des médiateurs de la douleur et de l’inflammation. Ces résultats suggèrent que l’extrait éthanolique de la partie aérienne de Fumaria capreolata possède un potentiel effet anti-inflammatoire et il présente également des effets analgésiques sur des modèles comportementaux chimiques de la douleur et de l’inflammation chez les souris.

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Authors and Affiliations

  1. Laboratoire de biotechnologies végétales et ethnobotanique, Faculté des sciences de la nature et de la vie, Université de Bejaia, 06000, Bejaia, Algeria

    N. Bribi, M. Belmouhoub & F. Maiza

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  1. N. Bribi
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  2. M. Belmouhoub
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  3. F. Maiza
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Correspondence to N. Bribi.

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Bribi, N., Belmouhoub, M. & Maiza, F. Anti-inflammatory and analgesic activities of ethanolic extract of Fumaria capreolata . Phytothérapie 15, 211–216 (2017). https://doi.org/10.1007/s10298-016-1035-6

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