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Engineered biosynthesis of biodegradable polymers

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  • Published:
Journal of Industrial Microbiology & Biotechnology

Abstract

Advances in science and technology have resulted in the rapid development of biobased plastics and the major drivers for this expansion are rising environmental concerns of plastic pollution and the depletion of fossil-fuels. This paper presents a broad view on the recent developments of three promising biobased plastics, polylactic acid (PLA), polyhydroxyalkanoate (PHA) and polybutylene succinate (PBS), well known for their biodegradability. The article discusses the natural and recombinant host organisms used for fermentative production of monomers, alternative carbon feedstocks that have been used to lower production cost, different metabolic engineering strategies used to improve product titers, various fermentation technologies employed to increase productivities and finally, the different downstream processes used for recovery and purification of the monomers and polymers.

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Abbreviations

PLA:

Polylactic acid

LAB:

Lactic acid bacteria

SSCF:

Simultaneous saccharification and co-fermentation

MCRB:

Membrane cell-recycle bioreactors

SCL:

Short chain length

MCL:

Medium chain length

PEG:

Polyethylene glycol

PHA:

Polyhydroxyalkanoates

PHB:

Polyhydroxybutyrate

PBS:

Polybutylene succinate

PE:

Polyethylene

PTT:

Polytrimethylene terephthalate

BDO:

Butanediol

EMP:

Embden-Meyerhof-Parnas

PK:

Pentose phosphoketolase

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Acknowledgments

This work was supported by the National Science Foundation (NSF) under the Center for Sustainable Polymers CHE-1413862.

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  1. University of Minnesota Twin Cities, Minneapolis, USA

    Pooja Jambunathan & Kechun Zhang

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  1. Pooja Jambunathan
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  2. Kechun Zhang
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Correspondence to Kechun Zhang.

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Jambunathan, P., Zhang, K. Engineered biosynthesis of biodegradable polymers. J Ind Microbiol Biotechnol 43, 1037–1058 (2016). https://doi.org/10.1007/s10295-016-1785-z

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  • DOI: https://doi.org/10.1007/s10295-016-1785-z

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