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Current approaches to exploit actinomycetes as a source of novel natural products

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Journal of Industrial Microbiology & Biotechnology

Abstract

For decades, microbial natural products have been one of the major sources of novel drugs for pharmaceutical companies, and today all evidence suggests that novel molecules with potential therapeutic applications are still waiting to be discovered from these natural sources, especially from actinomycetes. Any appropriate exploitation of the chemical diversity of these microbial sources relies on proper understanding of their biological diversity and other related key factors that maximize the possibility of successful identification of novel molecules. Without doubt, the discovery of platensimycin has shown that microbial natural products can continue to deliver novel scaffolds if appropriate tools are put in place to reveal them in a cost-effective manner. Whereas today innovative technologies involving exploitation of uncultivated environmental diversity, together with chemical biology and in silico approaches, are seeing rapid development in natural products research, maximization of the chances of exploiting chemical diversity from microbial collections is still essential for novel drug discovery. This work provides an overview of the integrated approaches developed at the former Basic Research Center of Merck Sharp and Dohme in Spain to exploit the diversity and biosynthetic potential of actinomycetes, and includes some examples of those that were successfully applied to the discovery of novel antibiotics.

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Acknowledgments

Authors worked at CIBE, Madrid, Spain until Natural Products at Merck came to an end in September 2008. Most of them are presently members of the scientific staff of the new Fundación MEDINA, Granada, Spain. The authors would like to acknowledge the contribution of all CIBE employees during the years of operation of the research center, and the support of many others at MSD de España who enabled the establishment of this nonprofit research organization that has ensured continuity of research into microbial natural products for more than 54 years.

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  1. Fundación MEDINA, Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Avda Conocimiento 3, Parque Tecnológico Ciencias de la Salud, 18100, Granada, Spain

    Olga Genilloud, Ignacio González, Jesus Martín, José Rubén Tormo & Francisca Vicente

  2. Genómica S.A., Alcarria, 7, Coslada, 28823, Madrid, Spain

    Oscar Salazar

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  1. Olga Genilloud
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Correspondence to Olga Genilloud.

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Genilloud, O., González, I., Salazar, O. et al. Current approaches to exploit actinomycetes as a source of novel natural products. J Ind Microbiol Biotechnol 38, 375–389 (2011). https://doi.org/10.1007/s10295-010-0882-7

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