Research Article

Clinical Autonomic Research

, Volume 21, Issue 6, pp 389-393

An alternative to treat palmar hyperhidrosis: use of oxybutynin

  • Nelson WoloskerAffiliated withDepartment of Vascular Surgery, Hospital das Clínicas, School of Medicine, University of São Paulo Email author 
  • , Jose R. de CamposAffiliated withDepartment of Thoracic Surgery, Hospital das Clínicas, School of Medicine, University of São Paulo
  • , Paulo KauffmanAffiliated withDepartment of Vascular Surgery, Hospital das Clínicas, School of Medicine, University of São Paulo
  • , Samantha NevesAffiliated withDepartment of Vascular Surgery, Hospital das Clínicas, School of Medicine, University of São Paulo
  • , Guilherme YazbekAffiliated withDepartment of Vascular Surgery, Hospital das Clínicas, School of Medicine, University of São Paulo
  • , Fabio B. JateneAffiliated withDepartment of Thoracic Surgery, Hospital das Clínicas, School of Medicine, University of São Paulo
  • , Pedro Puech-LeãoAffiliated withDepartment of Vascular Surgery, Hospital das Clínicas, School of Medicine, University of São Paulo

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Abstract

Purpose

To evaluate the effectiveness and patient satisfaction with the use of oxybutynin at low doses for treating palmar hyperhidrosis in a large series of patients.

Methods

From January 2007 to June 2009, 180 consecutive patients with palmar hyperhidrosis were treated with oxybutynin. Data were collected from 139 patients (41 patients were lost to follow-up). During the first week, patients received 2.5 mg of oxybutynin once per day; from the 8th to the 42nd day, 2.5 mg twice per day; and from the 43rd day to the end of the 12th week, 5 mg, twice per day. All of the patients underwent three evaluations before and after the oxybutynin treatment (at 6 and 12 weeks), using a clinical questionnaire and a clinical protocol for quality of life (QOL).

Results

More than 80% of the patients experienced an improvement in palmar hyperhidrosis. Most of the patients showed improvements in their QOL (74.6%). The side effects were minor, with dry mouth being the most frequent (70.5%).

Conclusion

The use of oxybutynin is an alternative as the first step in the treatment of palmar hyperhidrosis, given that it presents good results and improves QOL.

Keywords

Hyperhidrosis Quality of life Clinical treatment (oxybutynin)