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Effect of a hot water-soluble extraction from Grifola frondosa on the viability of a human monocyte cell line exposed to mitomycin C

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Mycoscience

Abstract

The effects of a hot water-soluble extract of Grifola frondosa on the viability of multiple immune cell lines were examined in vitro. The extract and the 1000-cut extract, a low molecular weight fraction, improved the viability of a human monocyte cell line, THP-1, treated by the anticancer drug mitomycin C. DNA microarray and immunoassay results revealed increases in interleukin (IL)-8 expression by THP-1 cells in response to the 1000-cut extract. These data suggest that the extract would enhance the immune system through induction of IL-8 production by human blood monocytes, which leads to activated neutrophils.

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Authors and Affiliations

  1. Department of Basic Educational Center for Pharmacy, Kobe Pharmaceutical University, 4-19-1 Motoyama-kitamachi, Higashinada-ku, Kobe, 658-8558, Japan

    Noriko Kodama

  2. Department of Medical Pharmaceutics, Kobe Pharmaceutical University, Kobe, Japan

    Shigeto Mizuno

  3. Department of Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan

    Akihiro Asakawa & Akio Inui

  4. Kobe Pharmaceutical University, 4-19-1 Motoyama-kitamachi, Higashinada-ku, Kobe, 658-8558, Japan

    Hiroaki Nanba

Authors
  1. Noriko Kodama
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  2. Shigeto Mizuno
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  3. Akihiro Asakawa
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  4. Akio Inui
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  5. Hiroaki Nanba
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Corresponding author

Correspondence to Noriko Kodama.

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Kodama, N., Mizuno, S., Asakawa, A. et al. Effect of a hot water-soluble extraction from Grifola frondosa on the viability of a human monocyte cell line exposed to mitomycin C. Mycoscience 51, 134–138 (2010). https://doi.org/10.1007/s10267-009-0016-0

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  • DOI: https://doi.org/10.1007/s10267-009-0016-0

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