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Increased levels of interleukin-33 in gingival crevicular fluids of patients with chronic periodontitis

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Abstract

The purpose of this clinical study is to comparatively investigate the interleukin-33 (IL-33) levels in gingival crevicular fluid (GCF), saliva and plasma of patients with periodontal disease as well as periodontally healthy subjects and the association between these levels and clinical parameters. GCF, saliva and plasma samples were collected from systemically healthy, non-smoker chronic periodontitis patients (CP group, n = 20), gingivitis patients (G group, n = 20) and periodontally healthy control groups (H group, n = 20). Full-mouth clinical periodontal parameters were also recorded. IL-33 levels were determined by ELISA. The total amount of GCF IL-33 was greater in the G and CP groups compared to the H group (p < 0.05). The GCF IL-33 concentration was significantly lower in the CP group than in the H and G groups (p < 0.001). Salivary or plasma IL-33 levels were similar in the study groups. The total amount of GCF IL-33 was positively correlated with the GI, PI and BOP (%) (p < 0.05). Considering the present findings, the increase in total amounts of GCF IL-33 may have a role in the pathogenesis of periodontal disease.

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Acknowledgments

No external funding, apart from the support of the authors, was available for this study. The authors thank the Assistant Professor Bülent Özkan (Department of Biostatistics and Medical Informatics, İzmir Katip Çelebi University, Faculty of Medicine) for providing statistical advice in this research.

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Authors and Affiliations

  1. Department of Periodontology, Faculty of Dentistry, Izmir Katip Celebi University, Aydınlık Evler Mah., Cemil Meriç Bulv., 6780 Sok. No: 48, 35640, Çiğli-Izmir, Turkey

    Mehmet Sağlam, Serhat Köseoğlu, Levent Savran & Tuğba Pekbağrıyanık

  2. Department of Periodontology, Faculty of Dentistry, Sifa University, Izmir, Turkey

    Cüneyt Asım Aral

  3. Research Center, Faculty of Dentistry, Izmir Katip Celebi University, Izmir, Turkey

    Ayşe Çetinkaya

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  1. Mehmet Sağlam
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  2. Serhat Köseoğlu
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  3. Cüneyt Asım Aral
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  4. Levent Savran
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  5. Tuğba Pekbağrıyanık
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  6. Ayşe Çetinkaya
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Correspondence to Levent Savran.

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Sağlam, M., Köseoğlu, S., Aral, C.A. et al. Increased levels of interleukin-33 in gingival crevicular fluids of patients with chronic periodontitis. Odontology 105, 184–190 (2017). https://doi.org/10.1007/s10266-016-0259-0

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  • DOI: https://doi.org/10.1007/s10266-016-0259-0

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