Skip to main content

Advertisement

SpringerLink
Log in

Inhibitory effect of alpha-mangostin on Candida biofilms

  • Short Communication
  • Published:
Odontology Aims and scope Submit manuscript

Abstract

The objective of this study was to determine the inhibitory effect of alpha-mangostin on Candida biofilms. Candida species including Candida albicans, Candida krusei, Candida tropicalis, and Candida glabrata were tested. Candida biofilms were formed in flat-bottomed 96-well microtiter plates. The metabolic activity of cells within biofilms was quantified using the XTT assay. The results demonstrated that alpha-mangostin showed a significant anti-biofilm effect on both developing biofilms and preformed biofilms of Candida species. It may be concluded that alpha-mangostin could be an anti-biofilm agent against Candida species. Further in vivo investigations are needed to uncover the therapeutic values of this medicinal plant.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

References

  1. Williams DW, Kuriyama T, Silva S, Malic S, Lewis MA. Candida biofilms and oral candidosis: treatment and prevention. Periodontol 2000. 2011;55(1):250–65.

    Article  PubMed  Google Scholar 

  2. Sanchez-Vargas LO, Estrada-Barraza D, Pozos-Guillen AJ, Rivas-Caceres R. Biofilm formation by oral clinical isolates of Candida species. Arch Oral Biol. 2013;58(10):1318–26.

    Article  PubMed  Google Scholar 

  3. ten Cate JM, Klis FM, Pereira-Cenci T, Crielaard W, de Groot PW. Molecular and cellular mechanisms that lead to Candida biofilm formation. J Dent Res. 2009;88(2):105–15.

    Article  PubMed  Google Scholar 

  4. Niimi M, Firth NA, Cannon RD. Antifungal drug resistance of oral fungi. Odontology. 2010;98(1):15–25.

    Article  PubMed  Google Scholar 

  5. Rautemaa R, Ramage G. Oral candidosis-clinical challenges of a biofilm disease. Crit Rev Microbiol. 2011;37(4):328–36.

    Article  PubMed  Google Scholar 

  6. Negri M, Salci TP, Shinobu-Mesquita CS, Capoci IR, Svidzinski TI, Kioshima ES. Early state research on antifungal natural products. Molecules. 2014;19(3):2925–56.

    Article  PubMed  Google Scholar 

  7. Jindarat S. Xanthones from mangosteen (Garcinia mangostana): multi-targeting pharmacological properties. J Med Assoc Thai. 2014;97(Suppl 2):S196–201.

    PubMed  Google Scholar 

  8. Gopalakrishnan G, Banumathi B, Suresh G. Evaluation of the antifungal activity of natural xanthones from Garcinia mangostana and their synthetic derivatives. J Nat Prod. 1997;60(5):519–24.

    Article  PubMed  Google Scholar 

  9. Kaomongkolgit R, Jamdee K, Chaisomboon N. Antifungal activity of alpha-mangostin against Candida albicans. J Oral Sci. 2009;51(3):401–6.

    Article  PubMed  Google Scholar 

  10. Yiemwattana I, Kaomongkolgit R. Alpha-mangostin suppresses IL-6 and IL-8 expression in P. gingivalis LPS-stimulated human gingival fibroblasts. Odontology. 2015;103(3):348–55.

    Article  PubMed  Google Scholar 

  11. Kaomongkolgit R. Alpha-mangostin suppresses MMP-2 and MMP-9 expression in head and neck squamous carcinoma cells. Odontology. 2013;101(2):227–32.

    Article  PubMed  Google Scholar 

  12. Taweechaisupapong S, Aiemsaard J, Chitropas P, Khunkiti W. Inhibitory effect of lemongrass oil and its major constituents on Candida biofilm and germ tube formation. S Afr J Bot. 2012;81:95–102.

    Article  Google Scholar 

  13. Costa AC, Pereira CA, Freire F, Junqueira JC, Jorge AO. Methods for obtaining reliable and reproducible results in studies of Candida biofilms formed in vitro. Mycoses. 2013;56(6):614–22.

    Article  PubMed  Google Scholar 

  14. Al-Massarani SM, El Gamal AA, Al-Musayeib NM, Mothana RA, Basudan OA, Al-Rehaily AJ, et al. Phytochemical, antimicrobial and antiprotozoal evaluation of Garcinia mangostana pericarp and α-mangostin, its major xanthone derivative. Molecules. 2013;18(9):10599–608.

    Article  PubMed  Google Scholar 

  15. Mohamed GA, Ibrahim SR, Shaaban MI, Ross SA. Mangostanaxanthones I and II, new xanthones from the pericarp of Garcinia mangostana. Fitoterapia. 2014;98:215–21.

    Article  PubMed  Google Scholar 

  16. Thein ZM, Samaranayake YH, Samaranayake LP. In vitro biofilm formation of Candida albicans and non-albicans Candida species under dynamic and anaerobic conditions. Arch Oral Biol. 2007;52(8):761–7.

    Article  PubMed  Google Scholar 

  17. Rossoni RD, Barbosa JO, Vilela SF, dos Santos JD, de Barros PP, Prata MC, et al. Competitive interactions between C. albicans, C. glabrata and C. krusei during biofilm formation and development of experimental candidiasis. PLoS One. 2015;10(7):e0131700.

    Article  PubMed  PubMed Central  Google Scholar 

  18. Obolskiy D, Pischel I, Siriwatanametanon N, Heinrich M. Garcinia mangostana L.: a phytochemical and pharmacological review. Phytother Res. 2009;23(8):1047–65.

    Article  PubMed  Google Scholar 

  19. Martins N, Barros L, Henriques M, Silva S, Ferreira I. Activity of phenolic compounds from plant origin against Candida species. Ind Crops Prod. 2015;74:648–70.

    Article  Google Scholar 

  20. Torrungruang K, Chutimaworapan S. Effect of mangosteen pericarp extract on cell viability in human gingival fibroblasts. CU Dent J. 2006;29:75–82.

    Google Scholar 

  21. Sampath D, Vijavaraghavan K. Cardioprotective effect of alpha-mangostin, a xanthone derivative from mangosteen on tissue defense system against isoproterenol-induced myocardial infarction in rats. J Biochem Mol Toxicol. 2007;21:336–9.

    Article  Google Scholar 

  22. Rassameemasmaung S, Sirikulsathean A, Amornchat C, Hirunrat K, Rojanapanthu P, Gritsanapan W. Effects of herbal mouthwash containing the pericarp extract of Garcinia mangostana L on halitosis, plaque and papillary bleeding index. J Int Acad Periodontol. 2007;9:19–25.

    PubMed  Google Scholar 

Download references

Acknowledgments

This work was supported by the grants from Naresuan University (Research grants from income of fiscal year 2014, the Grant Number: R2557C106). The authors would like to thank Assistant Professor Dr. Weeraya Tantanapornkul, instructor of Faculty of Dentistry, and Mr. Arthur John Pollock, instructor of Faculty of Humanities, Naresuan University, for editing the manuscript.

Author information

Authors and Affiliations

  1. Department of Oral Diagnosis, Faculty of Dentistry, Naresuan University, Phitsanulok, 65000, Thailand

    Ruchadaporn Kaomongkolgit

  2. Faculty of Dentistry, Dental Science Research Center, Naresuan University, Phitsanulok, 65000, Thailand

    Kusuma Jamdee

Authors
  1. Ruchadaporn Kaomongkolgit
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kusuma Jamdee
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ruchadaporn Kaomongkolgit.

Ethics declarations

Funding

This work was supported by the grants from Naresuan University (Research grants from income of fiscal year 2014, the Grant Number: R2557C106).

Conflict of interest

The authors declare that they have no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kaomongkolgit, R., Jamdee, K. Inhibitory effect of alpha-mangostin on Candida biofilms. Odontology 105, 248–253 (2017). https://doi.org/10.1007/s10266-016-0256-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10266-016-0256-3

Keywords

Search

Navigation