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T cells, mast cells and microvascular density in diffuse large B cell lymphoma

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Abstract

Diffuse large B cell lymphoma (DLBCL) is recognized as the most common form of non-Hodgkin lymphoma (NHL), accounting for about 40 % of all cases of NHL. Among the cellular components of the tumor inflammatory infiltrate, T cells and mast cells have been demonstrated to be correlated with tumor angiogenesis. In this report, we have investigated CD3 and tryptase expression and their relationship with microvascular density (MVD) in DLBCL patients. Moreover, we determined the significance of CD3 expression in bulky and non-bulky disease. CD3 expression was significantly lower in bulky disease patients when compared to non-bulky ones. CD3 showed a positive correlation with tryptase and MVD, while multiple regression analysis efficaciously predicted MVD depending on CD3 and tryptase as predictors, supporting a complex interplay between these cells in sustaining tumor angiogenesis in DLBCL patients.

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Acknowledgments

This work has been supported by the association against non-Hodgkin lymphomas “Il Sorriso di Antonio”, Corato, Italy, and by the European Union Seventh Framework Programme (FP7/2007–2013) under Grant agreement No. 278570 to DR.

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Authors and Affiliations

  1. Department of Basic Medical Sciences, Neurosciences, and Sensory Organs, University of Bari Medical School, Piazza Giulio Cesare, 11, 70124, Bari, Italy

    Christian Marinaccio, Simona Ruggieri, Beatrice Nico & Domenico Ribatti

  2. Department of Emergency and Transplantation, Pathology Section, University of Bari Medical School, Bari, Italy

    Giuseppe Ingravallo, Giuseppina Opinto & Eugenio Maiorano

  3. Department of Emergency and Transplantation, Hematology Section, University of Bari Medical School, Bari, Italy

    Francesco Gaudio, Tommasina Perrone & Giorgina Specchia

  4. National Cancer Institute “Giovanni Paolo II”, Bari, Italy

    Domenico Ribatti

Authors
  1. Christian Marinaccio
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  2. Giuseppe Ingravallo
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  3. Francesco Gaudio
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  4. Tommasina Perrone
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  5. Simona Ruggieri
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  6. Giuseppina Opinto
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  7. Beatrice Nico
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  8. Eugenio Maiorano
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  9. Giorgina Specchia
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  10. Domenico Ribatti
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Correspondence to Domenico Ribatti.

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Marinaccio, C., Ingravallo, G., Gaudio, F. et al. T cells, mast cells and microvascular density in diffuse large B cell lymphoma. Clin Exp Med 16, 301–306 (2016). https://doi.org/10.1007/s10238-015-0354-5

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  • DOI: https://doi.org/10.1007/s10238-015-0354-5

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