The Journal of Headache and Pain

, Volume 2, Supplement 1, pp s57–s60

GABA and glutamate in migraine

Authors

    • Headache and Related Disorders CenterPathology Unit, Este–Monselice Hospital
  • Franco Granella
    • Institute of NeurologyUniversity of Parma
  • Morena Cataldini
    • Department of NeurologyEste-Monselice Hospital
  • Flavio Verdelli
    • Headache and Related Disorders CenterPathology Unit, Este–Monselice Hospital
  • Tiziana Balbi
    • Headache and Related Disorders CenterPathology Unit, Este–Monselice Hospital
MIGRAINE AND PATHOPHYSIOLOGY

DOI: 10.1007/s101940170011

Cite this article as:
D’Andrea, G., Granella, F., Cataldini, M. et al. J Headache Pain (2001) 2: s57. doi:10.1007/s101940170011

Abstract

GABA and glutamic acid are the main inhibitory and excitatory neurotransmitters of central nervous system. Among other functions they modulate the pain threshold in the CNS. For this reason it has been hypothesized that anomalies of GABA and glutamate turn–over may play a role in migraine pathogenesis. In this review are discussed the evidences in favour of this hypothesis. A derangement of GABA may be an important factor in the occurrence of migraine attacks and their recurrence, whereas high level of glutamic acid may represent a biochemical marker of the neuronal hyperexcitability that may be the underlying cause of the aura. The pharmacological modulation of metabolism of both neurotransmitters is a promising approach to improve migraine therapy. In particular the studies presented here suggest that gabaergic drugs may be useful in migraine without aura, antiglutamatergic drugs are indicated to treat migraine with aura.

GABAGlutamic acidMigraine with and without auraMigraine pathogenesis

Copyright information

© Springer-Verlag Italia 2001