Guidelines

The Journal of Headache and Pain

, Volume 13, Issue 2, pp 31-70

Open Access This content is freely available online to anyone, anywhere at any time.

Italian guidelines for primary headaches: 2012 revised version

  • Paola SarchielliAffiliated withHeadache Centre, Neurologic Clinic, University of Perugia Email author 
  • , Franco GranellaAffiliated withNeurologic Clinic, University of Parma
  • , Maria Pia PrudenzanoAffiliated withHeadache Centre, Neurologic Clinic “L. Amaducci”, University of Bari
  • , Luigi Alberto PiniAffiliated withHeadache Centre, University of Reggio Emilia and Modena
  • , Vincenzo GuidettiAffiliated withDepartment of Child and Adolescent Neurology, Psychiatry and Rehabilitation, “Sapienza”, University of Rome
  • , Giorgio BonoAffiliated withNeurology Unit, Ospedale di Circolo e Fondazione Macchi, University of Insubria
  • , Lorenzo PinessiAffiliated withNeurologia II, Department of Neurology, Headache Centre, University of Turin
  • , Massimo AlessandriAffiliated withHeadache Centre, Department of Internal Medicine, Misericordia Hospital
  • , Fabio AntonaciAffiliated withHeadache Centre, Neurologic Clinic, University of PerugiaHeadache Science Centre, C. Mondino National Institute of Neurology Foundation IRCCSDepartment of Public Health, Neuroscience, Experimental and Forensic Medicine, University of Pavia
    • , Marcello FanciullacciAffiliated withHeadache Centre, Neurologic Clinic, University of Perugia
    • , Anna FerrariAffiliated withHeadache Centre, University of Reggio Emilia and Modena
    • , Mario GuazzelliAffiliated withHeadache Centre, Neurologic Clinic, University of PerugiaDepartment of Psychiatry, Neurobiology, Pharmacology and Biotechnologies, University of Pisa
    • , Giuseppe NappiAffiliated withHeadache Centre, Neurologic Clinic, University of PerugiaHeadache Science Centre, C. Mondino National Institute of Neurology Foundation IRCCS
    • , Grazia SancesAffiliated withHeadache Centre, Neurologic Clinic, University of PerugiaHeadache Science Centre, C. Mondino National Institute of Neurology Foundation IRCCS
    • , Giorgio SandriniAffiliated withHeadache Centre, Neurologic Clinic, University of PerugiaHeadache Science Centre, C. Mondino National Institute of Neurology Foundation IRCCSDepartment of Public Health, Neuroscience, Experimental and Forensic Medicine, University of Pavia
    • , Lidia SaviAffiliated withNeurologia II, Department of Neurology, Headache Centre, University of Turin
    • , Cristina TassorelliAffiliated withHeadache Centre, Neurologic Clinic, University of PerugiaHeadache Science Centre, C. Mondino National Institute of Neurology Foundation IRCCSDepartment of Public Health, Neuroscience, Experimental and Forensic Medicine, University of Pavia
    • , Giorgio ZanchinAffiliated withHeadache Centre, Neurologic Clinic, University of PerugiaDepartment of Neurosciences, Headache Centre, University of Padua

Abstract

The first edition of the Italian diagnostic and therapeutic guidelines for primary headaches in adults was published in J Headache Pain 2(Suppl. 1):105–190 (2001). Ten years later, the guideline committee of the Italian Society for the Study of Headaches (SISC) decided it was time to update therapeutic guidelines. A literature search was carried out on Medline database, and all articles on primary headache treatments in English, German, French and Italian published from February 2001 to December 2011 were taken into account. Only randomized controlled trials (RCT) and meta-analyses were analysed for each drug. If RCT were lacking, open studies and case series were also examined. According to the previous edition, four levels of recommendation were defined on the basis of levels of evidence, scientific strength of evidence and clinical effectiveness. Recommendations for symptomatic and prophylactic treatment of migraine and cluster headache were therefore revised with respect to previous 2001 guidelines and a section was dedicated to non-pharmacological treatment. This article reports a summary of the revised version published in extenso in an Italian version.

Keywords

Guidelines Primary headaches Symptomatic and prophylactic treatment Pharmacological and non pharmacological