Rapid Communication

The Journal of Headache and Pain

, Volume 11, Issue 2, pp 151-156

Open Access This content is freely available online to anyone, anywhere at any time.

Frequencies of genetic polymorphisms related to triptans metabolism in chronic migraine

  • Giovanna GentileAffiliated withDepartment of Biochemical Sciences, Advanced Molecular Diagnostic Unit, 2nd School of Medicine, Sapienza University, Sant’Andrea Hospital
  • , Serena MissoriAffiliated withDepartment of Medical and Molecular Sciences, Regional Referral Headache Center, 2nd School of Medicine, Sapienza University, Sant’Andrea Hospital
  • , Marina BorroAffiliated withDepartment of Biochemical Sciences, Advanced Molecular Diagnostic Unit, 2nd School of Medicine, Sapienza University, Sant’Andrea Hospital
  • , Alisa SebastianelliAffiliated withDepartment of Medical and Molecular Sciences, Regional Referral Headache Center, 2nd School of Medicine, Sapienza University, Sant’Andrea Hospital
  • , Maurizio SimmacoAffiliated withDepartment of Biochemical Sciences, Advanced Molecular Diagnostic Unit, 2nd School of Medicine, Sapienza University, Sant’Andrea Hospital
  • , Paolo MartellettiAffiliated withDepartment of Medical and Molecular Sciences, Regional Referral Headache Center, 2nd School of Medicine, Sapienza University, Sant’Andrea Hospital Email author 

Abstract

Chronic migraine (CM) prevalence ranges around 1–5%. Most of these patients usually treat their acute attacks with triptans, whose efficacy is extremely variable. A genetic basis for migraine is evident and many susceptibility genes have been described, as well as gene polymorphisms possibly implied in therapy response. Several factors could be involved in the evolution of episodic migraine into a chronic form, such as natural history, psychiatric comorbidity, and the individual’s response to therapy. During a study aimed at detecting connections between genotype and response to triptans administration, we characterized a CM population for polymorphisms in the genes coding for monoamine oxidase A, g-protein beta 3 and the cytochromes CYP3A4 and CYP1A2. Alleles and genotypes distributions were compared with known frequencies of healthy Caucasian populations. A significant association with CM was found for the long allele of monoamine oxidase A 30 bp VNTR and CYP1A2*1F variant. Such genomic analysis is part of an integrated platform able to evaluate different levels of metabolic pathways of drugs in CM and their influence in the chronicization process.

Keywords

Chronic migraine Triptans Pyrosequencing Pharmacogenomics Genetic liability