The Journal of Headache and Pain

, Volume 8, Issue 5, pp 273–276

Parenteral vs. oral sumatriptan and naratriptan: plasma levels and efficacy in migraine. A comment

Authors

    • Danish Headache Centre Department of NeurologyUniversity of Copenhagen Glostrup Hospital
Open AccessComment

DOI: 10.1007/s10194-007-0411-x

Abstract

The clinical efficacy in migraine was compared for oral and subcutaneous sumatriptan and naratriptan. Doses of the two administration forms were chosen as resulting in comparable blood concentrations. Subcutaneous administrations of the drugs were superior for efficacy than the oral forms. This most likely due to a quicker rise in blood concentrations after subcutaneous injections.. In designing new therapies for migraine one should aim at a quick absorption of the drug, which will probably result in an increased efficacy.

Keywords

Migraine Sumatriptan Naratriptan Oral administration Subcutaneous administration

Copyright information

© Springer-Verlag Italia 2007