Original

The Journal of Headache and Pain

, Volume 8, Issue 3, pp 167-174

Open Access This content is freely available online to anyone, anywhere at any time.

Effects of remote cutaneous pain on trigeminal laser-evoked potentials in migraine patients

  • Marina de TommasoAffiliated withNeurophysiopathology of Chronic Pain Unit, Neurological and Psychiatric Sciences Department, University of Bari, Clinica Neurologica, Policlinico Email author 
  • , Olimpia DifruscoloAffiliated withNeurophysiopathology of Chronic Pain Unit, Neurological and Psychiatric Sciences Department, University of Bari, Clinica Neurologica, Policlinico
  • , Michele SardaroAffiliated withNeurophysiopathology of Chronic Pain Unit, Neurological and Psychiatric Sciences Department, University of Bari, Clinica Neurologica, Policlinico
  • , Giuseppe LibroAffiliated withNeurophysiopathology of Chronic Pain Unit, Neurological and Psychiatric Sciences Department, University of Bari, Clinica Neurologica, Policlinico
  • , Carla PecoraroAffiliated withNeurophysiopathology of Chronic Pain Unit, Neurological and Psychiatric Sciences Department, University of Bari, Clinica Neurologica, Policlinico
  • , Claudia SerpinoAffiliated withNeurophysiopathology of Chronic Pain Unit, Neurological and Psychiatric Sciences Department, University of Bari, Clinica Neurologica, Policlinico
  • , Paolo LambertiAffiliated withNeurophysiopathology of Chronic Pain Unit, Neurological and Psychiatric Sciences Department, University of Bari, Clinica Neurologica, Policlinico
  • , Paolo LivreaAffiliated withNeurophysiopathology of Chronic Pain Unit, Neurological and Psychiatric Sciences Department, University of Bari, Clinica Neurologica, Policlinico

Abstract

The present study aimed to evaluate heat pain thresholds and evoked potentials following CO2 laser thermal stimulation (laser-evoked potentials, LEPs), during remote application of capsaicin, in migraine patients vs. non-migraine healthy controls. Twelve outpatients suffering from migraine without aura were compared with 10 healthy controls. The LEPs were recorded by 6 scalp electrodes, stimulating the dorsum of the right hand and the right supraorbital zone in basal condition, during the application of 3% capsaicin on the dorsum of the left hand and after capsaicin removal. In normal subjects, the laser pain and the N2-P2 vertex complex obtained by the hand and face stimulation were significantly reduced during remote capsaicin application, with respect to pre-and post-capsaicin conditions, while in migraine LEPs and laser pain were not significantly modified during remote painful stimulation. In migraine a defective brainstem inhibiting control may coexist with cognitive factors of focalised attention to facial pain, less sensitive to distraction by a second pain.

Keywords

Migraine Laser-evoked potentials Diffuse noxious inhibiting control