The Journal of Headache and Pain

, Volume 8, Issue 3, pp 167–174

Effects of remote cutaneous pain on trigeminal laser-evoked potentials in migraine patients

Authors

    • Neurophysiopathology of Chronic Pain Unit, Neurological and Psychiatric Sciences DepartmentUniversity of Bari, Clinica Neurologica, Policlinico
  • Olimpia Difruscolo
    • Neurophysiopathology of Chronic Pain Unit, Neurological and Psychiatric Sciences DepartmentUniversity of Bari, Clinica Neurologica, Policlinico
  • Michele Sardaro
    • Neurophysiopathology of Chronic Pain Unit, Neurological and Psychiatric Sciences DepartmentUniversity of Bari, Clinica Neurologica, Policlinico
  • Giuseppe Libro
    • Neurophysiopathology of Chronic Pain Unit, Neurological and Psychiatric Sciences DepartmentUniversity of Bari, Clinica Neurologica, Policlinico
  • Carla Pecoraro
    • Neurophysiopathology of Chronic Pain Unit, Neurological and Psychiatric Sciences DepartmentUniversity of Bari, Clinica Neurologica, Policlinico
  • Claudia Serpino
    • Neurophysiopathology of Chronic Pain Unit, Neurological and Psychiatric Sciences DepartmentUniversity of Bari, Clinica Neurologica, Policlinico
  • Paolo Lamberti
    • Neurophysiopathology of Chronic Pain Unit, Neurological and Psychiatric Sciences DepartmentUniversity of Bari, Clinica Neurologica, Policlinico
  • Paolo Livrea
    • Neurophysiopathology of Chronic Pain Unit, Neurological and Psychiatric Sciences DepartmentUniversity of Bari, Clinica Neurologica, Policlinico

DOI: 10.1007/s10194-007-0385-8

Abstract

The present study aimed to evaluate heat pain thresholds and evoked potentials following CO2 laser thermal stimulation (laser-evoked potentials, LEPs), during remote application of capsaicin, in migraine patients vs. non-migraine healthy controls. Twelve outpatients suffering from migraine without aura were compared with 10 healthy controls. The LEPs were recorded by 6 scalp electrodes, stimulating the dorsum of the right hand and the right supraorbital zone in basal condition, during the application of 3% capsaicin on the dorsum of the left hand and after capsaicin removal. In normal subjects, the laser pain and the N2-P2 vertex complex obtained by the hand and face stimulation were significantly reduced during remote capsaicin application, with respect to pre-and post-capsaicin conditions, while in migraine LEPs and laser pain were not significantly modified during remote painful stimulation. In migraine a defective brainstem inhibiting control may coexist with cognitive factors of focalised attention to facial pain, less sensitive to distraction by a second pain.

Keywords

Migraine Laser-evoked potentials Diffuse noxious inhibiting control

Copyright information

© Springer-Verlag Italia 2007