PATHOPHYSIOLOGY OF HEADACHES

The Journal of Headache and Pain

, Volume 6, Issue 4, pp 195-198

Open Access This content is freely available online to anyone, anywhere at any time.

Habituation of single CO2 laser–evoked responses during interictal phase of migraine

  • M. de TommasoAffiliated withClinica Neurologica, PoliclinicoNeurological and Psychiatric Sciences Department, University of Bari Email author 
  • , G. LibroAffiliated withNeurological and Psychiatric Sciences Department, University of Bari
  • , M. GuidoAffiliated withNeurological and Psychiatric Sciences Department, University of Bari
  • , L. LositoAffiliated withNeurological and Psychiatric Sciences Department, University of Bari
  • , P. LambertiAffiliated withNeurological and Psychiatric Sciences Department, University of Bari
  • , P. LivreaAffiliated withNeurological and Psychiatric Sciences Department, University of Bari

Abstract

A reduced habituation of averaged laser–evoked potential (LEP) amplitudes was previously found in migraine patients. The aim of the present study was to assess the habituation of single LEP responses and pain sensation during the interictal phase in migraine patients. Fourteen migraine patients were compared with ten control subjects. The pain stimulus was laser pulses, generated by CO2 laser, delivered to right supraorbital zone. Patients were evaluated during attack–free conditions. The LEP habituation was studied by measuring the changes of LEP amplitudes across and within three consecutive repetitions of 21 non–averaged trials. In migraine patients the N2–P2 wave amplitudes did not show a tendency toward habituation across and, above all, within the three repetitions. Anomalous behaviour of nociceptive cortex during the interictal phase of migraine may predispose patients to headache occurrence and persistence.

Key words

Migraine Laser-evoked potentials Habituation