ORIGINAL ARTICLE

Modern Rheumatology

, Volume 15, Issue 1, pp 37-40

Doppler sonographic evaluation of effect of treatment with infliximab (Remicade) for rheumatoid arthritis

  • Atsushi TakahashiAffiliated withDivision of Rheumatology, Ohta Nishinouchi Hospital Email author 
  • , Ai SatoAffiliated withDivision of Rheumatology, Ohta Nishinouchi Hospital
  • , Yukio YamaderaAffiliated withPhysiological Examination Unit, Ohta Nishinouchi Hospital
  • , Isao TakedaAffiliated withDivision of Rheumatology, Ohta Nishinouchi Hospital
  • , Takashi KannoAffiliated withDivision of Rheumatology, Ohta Nishinouchi Hospital
  • , Yoshito OhguchiAffiliated withOhguchi Clinic
  • , Tomoe NishimakiAffiliated withNishimaki Clinic
  • , Reiji KasukawaAffiliated withDivision of Rheumatology, Ohta Nishinouchi Hospital

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Abstract

Synovial vascularization in the knee joints of six patients with rheumatoid arthritis who were treated with infliximab was evaluated by Doppler sonography. Power Doppler sonography demonstrated a significant reduction of color flow signals (P < 0.05), and spectral Doppler sonography demonstrated a significant increase in vascular resistance (P < 0.05) at week 6 (after three injections) evaluation of the therapy. A significant decrease in the number of tender joints (P < 0.05) and C-reactive protein value (P < 0.05) was also observed in these patients.

Key words

Doppler sonography Infliximab Resistive index (RI) Rheumatoid arthritis (RA) Synovial vascularization