Modern Rheumatology

, Volume 15, Issue 1, pp 37–40

Doppler sonographic evaluation of effect of treatment with infliximab (Remicade) for rheumatoid arthritis

  • Atsushi Takahashi
  • Ai Sato
  • Yukio Yamadera
  • Isao Takeda
  • Takashi Kanno
  • Yoshito Ohguchi
  • Tomoe Nishimaki
  • Reiji Kasukawa
ORIGINAL ARTICLE

DOI: 10.1007/s10165-004-0359-5

Cite this article as:
Takahashi, A., Sato, A., Yamadera, Y. et al. Mod Rheumatol (2005) 15: 37. doi:10.1007/s10165-004-0359-5

Abstract

Synovial vascularization in the knee joints of six patients with rheumatoid arthritis who were treated with infliximab was evaluated by Doppler sonography. Power Doppler sonography demonstrated a significant reduction of color flow signals (P < 0.05), and spectral Doppler sonography demonstrated a significant increase in vascular resistance (P < 0.05) at week 6 (after three injections) evaluation of the therapy. A significant decrease in the number of tender joints (P < 0.05) and C-reactive protein value (P < 0.05) was also observed in these patients.

Key words

Doppler sonographyInfliximabResistive index (RI)Rheumatoid arthritis (RA)Synovial vascularization

Copyright information

© Japan College of Rheumatology and Springer-Verlag Tokyo 2005

Authors and Affiliations

  • Atsushi Takahashi
    • 1
  • Ai Sato
    • 1
  • Yukio Yamadera
    • 2
  • Isao Takeda
    • 1
  • Takashi Kanno
    • 1
  • Yoshito Ohguchi
    • 3
  • Tomoe Nishimaki
    • 4
  • Reiji Kasukawa
    • 1
  1. 1.Division of RheumatologyOhta Nishinouchi HospitalKoriyamaJapan
  2. 2.Physiological Examination UnitOhta Nishinouchi HospitalKoriyamaJapan
  3. 3.Ohguchi ClinicKoriyamaJapan
  4. 4.Nishimaki ClinicSukagawaJapan
  5. 5.Second Department of Internal MedicineFukushima Medical University, School of MedicineFukushimaJapan