Abstract
Poorer hearing in the presence of background noise is a significant problem for the hearing impaired. Ototoxic drugs, ageing, and noise exposure can damage the sensory hair cells of the inner ear that are essential for normal hearing sensitivity. The relationship between outer hair cell (OHC) loss and progressively poorer hearing sensitivity in quiet or in competing background noise is supported by a number of human and animal studies. In contrast, the effect of moderate inner hair cell (IHC) loss or dysfunction shows almost no impact on behavioral measures of hearing sensitivity in quiet, when OHCs remain intact, but the relationship between selective IHC loss and hearing in noise remains relatively unknown. Here, a moderately high dose of carboplatin (75 mg/kg) that produced IHC loss in chinchillas ranging from 40 to 80 % had little effect on thresholds in quiet. However, when tested in the presence of competing broadband (BBN) or narrowband noise (NBN), thresholds increased significantly. IHC loss >60 % increased signal-to-noise ratios (SNRs) for tones (500–11,300 Hz) in competing BBN by 5–10 dB and broadened the masking function under NBN. These data suggest that IHC loss or dysfunction may play a significant role in listening in noise independent of OHC integrity and that these deficits may be present even when thresholds in quiet are within normal limits.
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Abbreviations
- ABR:
-
Auditory brainstem response
- AC:
-
Auditory cortex
- CAP:
-
Compound action potential
- CM:
-
Cochlear microphonics
- dB:
-
Decibel
- DPOAE:
-
Distortion product otoacoustic emissions
- IC:
-
Inferior colliculus
- IHC:
-
Inner hair cell
- OHC:
-
Outer hair cell
- PTCs:
-
Psychophysical tuning curves
- SD:
-
Standard deviation
- SEM:
-
Standard error of the mean
- SPL:
-
Sound pressure level
- SDH:
-
Succinate dehydrogenase
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Acknowledgments
The corresponding author gratefully acknowledges Colleen Le Prell for guidance and constructive review on the contents and revisions of the manuscript.
Author Contributions
EL and DD performed data collection and analysis, and all authors contributed to writing the manuscript.
Support
Research reported in this manuscript was supported by the National Institute on Deafness and Other Communication Disorders (NIDCD) of the National Institutes of Health (NIH) under award number R03 DC011612-04. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
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Lobarinas, E., Salvi, R. & Ding, D. Selective Inner Hair Cell Dysfunction in Chinchillas Impairs Hearing-in-Noise in the Absence of Outer Hair Cell Loss. JARO 17, 89–101 (2016). https://doi.org/10.1007/s10162-015-0550-8
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DOI: https://doi.org/10.1007/s10162-015-0550-8