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Does significant renal ablation truly and invariably lead to hyperfiltration and progressive chronic kidney disease?

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Abstract

It is generally believed that significant renal ablation leads to hyperfiltration and eventually progressively worsening chronic kidney disease. The data behind this belief have not been scrutinized intensively. More importantly, the above belief leads many physicians to manage patients differently than they otherwise would manage. Here, we examine the data behind whether hyperfiltration occurs when patients lose kidney mass (by excision or by disease) and whether the hyperfiltration is uniformly injurious.

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Authors and Affiliations

  1. Division of Nephrology, San Francisco General Hospital, University of California, 1001 Potrero Ave, Building 100, Rm 342, San Francisco, CA, 94110-1341, USA

    Andrew Wang & Ramin Sam

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  1. Andrew Wang
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  2. Ramin Sam
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Correspondence to Ramin Sam.

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The authors have declared that no conflict of interest exists.

This article does not contain any studies with human participants or animals performed by any of the authors.

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Wang, A., Sam, R. Does significant renal ablation truly and invariably lead to hyperfiltration and progressive chronic kidney disease?. Clin Exp Nephrol 21, 367–374 (2017). https://doi.org/10.1007/s10157-016-1342-0

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  • DOI: https://doi.org/10.1007/s10157-016-1342-0

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