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Serum uric acid levels and mortality in the Japanese population: the Yamagata (Takahata) study

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Abstract

Background

Serum uric acid level is regulated by gender, dietary habit, genetic predisposition, and renal function, and is associated with the development of renal and cardiovascular diseases. This study prospectively investigated the association between serum uric acid levels and mortality in a community-based population.

Methods

Three thousand four hundred and eighty-seven subjects regardless of the antihyperuricemic medication (45 % male; mean age 62 years old) from the Takahata town in Japan participated in this study and were followed up for 8 years (median 7.5 years). We examined the association between serum uric acid levels at baseline and the all-cause and cardiovascular mortality, respectively, in this population.

Results

One hundred seventy-nine subjects died during the follow-up period, with 49 deaths attributed to cardiovascular causes. Kaplan–Meier analysis revealed that the all-cause mortality was significantly higher along with the increase in serum uric acid levels at baseline among female (Log-rank P < 0.01), but not male subjects (P = 0.97). Cox-proportional hazard model analysis with adjustment for possible confounders including age, renal function, and comorbidities revealed that hyperuricemia (uric acid ≥7.0 mg/dL) was an independent risk factor for all-cause and cardiovascular mortality, respectively, in female [hazard ratio (HR) 5.92, 95 % confidence interval (CI) 2.10–14.6 for all-cause mortality, and HR 10.7, 95 % CI 1.76–50.2 for cardiovascular mortality], but not male subjects.

Conclusion

Hyperuricemia was an independent risk for all-cause and cardiovascular mortality in female, but not among the male subjects in a community-based population.

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Acknowledgments

This study was supported in part by a Grant-in-Aid from the 21st Century Center of Excellence (COE) and Global COE program of the Japan Society for the Promotion of Science and by a Grant-in-Aid for Scientific Research (C) (15K09240).

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Authors and Affiliations

  1. Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, 2-2-2, Iida-Nishi, Yamagata, 990-9585, Japan

    Keita Kamei, Tsuneo Konta, Kazunobu Ichikawa, Hiroko Sato, Natsuko Suzuki, Asami Kabasawa, Kazuko Suzuki, Atsushi Hirayama, Yoko Shibata, Tetsu Watanabe & Isao Kubota

  2. Global COE, Yamagata University School of Medicine, Yamagata, Japan

    Takeo Kato, Yoshiyuki Ueno & Takamasa Kayama

Authors
  1. Keita Kamei
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  2. Tsuneo Konta
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  3. Kazunobu Ichikawa
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  4. Hiroko Sato
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  5. Natsuko Suzuki
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  6. Asami Kabasawa
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  7. Kazuko Suzuki
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  8. Atsushi Hirayama
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  9. Yoko Shibata
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  10. Tetsu Watanabe
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  11. Takeo Kato
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  12. Yoshiyuki Ueno
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  13. Takamasa Kayama
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  14. Isao Kubota
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Corresponding author

Correspondence to Tsuneo Konta.

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All of the authors declare no competing financial interests.

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Kamei, K., Konta, T., Ichikawa, K. et al. Serum uric acid levels and mortality in the Japanese population: the Yamagata (Takahata) study. Clin Exp Nephrol 20, 904–909 (2016). https://doi.org/10.1007/s10157-016-1228-1

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  • DOI: https://doi.org/10.1007/s10157-016-1228-1

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