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Reference glomerular filtration rate levels in Japanese children: using the creatinine and cystatin C based estimated glomerular filtration rate

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Abstract

Background

The present study was performed to determine the reference values of glomerular filtration rate (GFR) in children by age using the new eGFR equations derived from serum creatinine (Cr) and cystatine C (cysC).

Methods

A total of 1137 children (509 males and 628 females) between the ages of 3 months and 16 years presenting at our facilities between 2008 and 2009 without diseases affecting the renal function were included in this study as in our previous reports for reference values of serum Cr and cysC. We calculated eGFR with the Cr based equation in children aged 2–16 years, and with the cysC based equation in those aged 3–23 months, and determined the reference values of GFR in Japanese children by each age group.

Results

We reviewed the median, 2.5 and 97.5 percentile of GFR reference value in each age group. The medians of reference GFRs are 91.7, 98.5, 106.3, and 113.1 mL/min/1.73 m2 in children aged 3–5, 6–11, 12–17, and 18 months–16 years, respectively.

Conclusion

We determined the normal reference values of GFR in children. It is important for pediatricians who examine pediatric chronic kidney disease patients to know the values of normal renal function.

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Acknowledgments

Financial support from the Kidney Foundation, Japan, enabled us to examine blood and urine specimens collected throughout Japan. We thank Takeshi Matsuyama, MD, Yohei Ikezumi, MD, Midori Awazu, MD, Takashi Sekine, MD, Takuji Yamada, MD, Yuko Akioka, MD, Hirotsugu Kitayama, MD, Mayumi Sako, MD, Masataka Hisano, MD and Kazumoto Iijima, MD, of the Committee of Measures for Pediatric CKD, for their contributions to the improvement of this manuscript.

Conflict of interest

The authors have declared that no conflict of interest exists.

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Authors and Affiliations

  1. The Committee of Measures for Pediatric CKD, The Japanese Society for Pediatric Nephrology, Tokyo, Japan

    Osamu Uemura, Takuhito Nagai, Kenji Ishikura, Shuichi Ito, Hiroshi Hataya, Yoshimitsu Gotoh, Naoya Fujita, Yuko Akioka, Tetsuji Kaneko & Masataka Honda

  2. Department of Pediatric Nephrology, Aichi Children’s Health and Medical Center, 1-2 Osakada Morioka-cho, Obu, Aichi, 474-8710, Japan

    Osamu Uemura

Authors
  1. Osamu Uemura
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  2. Takuhito Nagai
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  3. Kenji Ishikura
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  4. Shuichi Ito
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  5. Hiroshi Hataya
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  6. Yoshimitsu Gotoh
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  7. Naoya Fujita
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  8. Yuko Akioka
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  9. Tetsuji Kaneko
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  10. Masataka Honda
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Corresponding author

Correspondence to Osamu Uemura.

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Uemura, O., Nagai, T., Ishikura, K. et al. Reference glomerular filtration rate levels in Japanese children: using the creatinine and cystatin C based estimated glomerular filtration rate. Clin Exp Nephrol 19, 683–687 (2015). https://doi.org/10.1007/s10157-014-1042-6

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  • DOI: https://doi.org/10.1007/s10157-014-1042-6

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