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Urinary angiotensinogen level is increased in preterm neonates

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Abstract

Background

All components of the renin–angiotensin system (RAS) are abundantly synthesized in the developing kidney, suggesting that the RAS plays an important role in renal development. To examine this system in human neonates, we measured urinary angiotensinogen levels in preterm and full-term neonates and examined the relationship between urinary angiotensinogen levels and gestational age.

Methods

Urine and plasma samples were collected from 20 preterm and 18 full-term neonates at birth. Angiotensinogen levels were measured using enzyme-linked immunosorbent assay.

Results

Plasma angiotensinogen concentrations were not increased in preterm neonates compared with that in full-term neonates (P = 0.7288). However, the urinary angiotensinogen-to-creatinine ratio was significantly higher in preterm neonates compared with that in full-term neonates (P = 0.0011). Importantly, the urinary angiotensinogen-to-creatinine ratio dropped significantly with increasing gestational age (P = 0.0010), whereas the plasma angiotensinogen concentration was not correlated with gestational age (P = 0.7814).

Conclusions

These results suggest that urinary angiotensinogen levels may indicate the involvement of intrarenal RAS activation in prenatal renal development.

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Acknowledgments

The authors acknowledge excellent technical assistance from Mrs. Naomi Okamoto. This study was supported by JSPS KAKENHI Grant Numbers 23591569 and 23591570.

Conflict of interest

The authors declare no conflict of interests.

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Authors and Affiliations

  1. Department of Pediatrics, Institute of Health Biosciences, The University of Tokushima Graduate School, Kuramoto-cho 3-18-15, Tokushima, Tokushima, 770-8503, Japan

    Masashi Suzue, Maki Urushihara, Ryuji Nakagawa, Takahiko Saijo & Shoji Kagami

Authors
  1. Masashi Suzue
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  2. Maki Urushihara
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  3. Ryuji Nakagawa
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  4. Takahiko Saijo
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  5. Shoji Kagami
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Corresponding author

Correspondence to Maki Urushihara.

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Cite this article

Suzue, M., Urushihara, M., Nakagawa, R. et al. Urinary angiotensinogen level is increased in preterm neonates. Clin Exp Nephrol 19, 293–297 (2015). https://doi.org/10.1007/s10157-014-0977-y

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  • DOI: https://doi.org/10.1007/s10157-014-0977-y

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