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ANCA-associated vasculitis: report from Korea

  • Review Article
  • The Asia Pacific Meeting of Vasculitis and ANCA Workshop 2012
  • Published:
Clinical and Experimental Nephrology Aims and scope Submit manuscript

Abstract

We investigated the clinical features of Korean patients with anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) by reviewing the literature. The characteristics of AAV in Korean patients were as follows: (1) granulomatous and limited disease is prevalent in granulomatosis with polyangiitis (Wegener’s) (GPA), (2) ANCA positivity is lower in GPA (56.6–68.9 %) and eosinophilic granulomatosis with polyangiitis (EGPA) (5.9–8.3 %), whereas it is higher in microscopic polyangiitis (MPA) (69–94 %), (3) C-ANCA/proteinase 3 (PR3)-ANCA positivity is 71.5–100 % in GPA and P-ANCA/myeloperoxidase (MPO)-ANCA positivity reached 94–100 % in patients with MPA, (4) renal involvement or progression to end-stage renal disease was lower in Korean patients with GPA and EGPA than in Caucasians with GPA and EGPA (according to data provided in reports). The data provided here may need to be confirmed in large-scale studies.

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Acknowledgments

This work was supported by the MKE/KEIT R&D program (Grant No. 10035615) and by the World Class University program of MEST and the NRF (Grant No. R31-2008-000-10103-0).

Conflict of interest

All the authors have declared no competing interest.

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Authors and Affiliations

  1. Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 110-744, Korea

    Hye Won Kim & Yeong Wook Song

  2. WCU Department of Molecular Medicine and Biopharmaceutical Sciences, Medical Research Institute, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul, 110-799, Korea

    Yeong Wook Song

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  1. Hye Won Kim
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Correspondence to Yeong Wook Song.

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Kim, H.W., Song, Y.W. ANCA-associated vasculitis: report from Korea. Clin Exp Nephrol 17, 708–711 (2013). https://doi.org/10.1007/s10157-012-0754-8

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  • DOI: https://doi.org/10.1007/s10157-012-0754-8

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