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Genetics of ANCA-associated vasculitis in Japan: a role for HLA-DRB1*09:01 haplotype

  • Review Article
  • The Asia Pacific Meeting of Vasculitis and ANCA Workshop 2012
  • Published:
Clinical and Experimental Nephrology Aims and scope Submit manuscript

Abstract

The epidemiology of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is considerably different between European and Asian populations. Whereas granulomatosis with polyangiitis is the most common form of AAV in northern European populations, microscopic polyangiitis (MPA) accounts for the majority of AAV in Japan. This difference may at least in part derive from the difference in genetic background. In this review, I focus on our observation on HLA, an obvious candidate gene for immune disorders, and discuss its potential implication. In Japanese AAV, significant association was detected with HLA-DRB1*09:01, the carrier frequency of which was increased in MPA [P = 0.0087, odds ratio (OR) 1.90, 95 % confidence interval (CI) 1.17–3.08] and in myeloperoxidase (MPO)-ANCA-positive AAV (P = 0.0016, OR 2.05, 95 % CI 1.31–3.23) when compared with healthy Japanese controls. HLA-DRB1*09:01 is one of the most common HLA-DRB1 alleles in Asians but is rare in Caucasian populations. Interestingly, HLA-DRB1*09:01 has been shown to be associated with multiple autoimmune diseases, including type 1 diabetes, rheumatoid arthritis, and systemic lupus erythematosus, suggesting that either HLA-DRB1*09:01 itself or other genes in tight linkage disequilibrium may play a role in a molecular pathway shared by various autoimmune diseases in Japanese and possibly in other Asian populations.

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Acknowledgments

The work discussed in this study was supported by a grant-in-aid from the Ministry of Health, Labor, and Welfare of Japan.

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The author has declared no competing interest.

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Authors and Affiliations

  1. Molecular and Genetic Epidemiology Laboratory, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan

    Naoyuki Tsuchiya

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  1. Naoyuki Tsuchiya
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Correspondence to Naoyuki Tsuchiya.

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Tsuchiya, N. Genetics of ANCA-associated vasculitis in Japan: a role for HLA-DRB1*09:01 haplotype. Clin Exp Nephrol 17, 628–630 (2013). https://doi.org/10.1007/s10157-012-0691-6

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  • DOI: https://doi.org/10.1007/s10157-012-0691-6

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