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Protein-energy wasting and peritoneal function in elderly peritoneal dialysis patients

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Abstract

Background

Nutritional status is important in peritoneal dialysis (PD) patients. We aimed to compare the peritoneal transport (PT) characteristics and indicators of nutritional status in elderly and non-elderly PD patients.

Methods

One-hundred and four consecutive patients were divided into either the elderly (>65 years old; n = 44) or the non-elderly (≤65 years old; n = 60) group. PT was assessed via the peritoneal equilibration test, Kt/V (K dialyzer clearance of urea, t dialysis time, V volume of distribution of urea), total creatinine clearance (CrCl), and glomerular filtration rate. Subjective global assessment (SGA), serum albumin (ALB), hemoglobin, prealbumin (PA), transferrin (TF), fat-free edema-free body mass (fat-free edema-free BM), and normalized protein intake (nPNA) were determined, and were used to indicate nutritional status.

Results

Elderly PD patients had higher dialysate to plasma creatinine ratios (D/P Cr) and CrCl, but lower serum creatinine body weights, ALB, PA, TF, fat-free edema-free BM, SGA, and nPNA than the non-elderly group. Multivariate analysis indicated that, after adjusting for PD time, body weight, diabetes mellitus, age, and sex, SGA negatively correlated with D/P Cr, whereas after adjusting for PD time, diabetes mellitus, and sex, D/P Cr positively correlated with age in all patients.

Conclusions

Protein-energy wasting and a high PT are more common in elderly than non-elderly PD patients. Nutritional status should be carefully considered when prescribing the PD dose and frequency, especially in elderly patients.

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Acknowledgments

We would like to thank all patients for allowing access to their records, and Mengjiang Bao and Shuying Li for technical assistance.

Conflict of interest

The authors declare no conflicts of interest.

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Authors and Affiliations

  1. Department of Nephrology, The Second Affiliated Hospital, Harbin Medical University, 246 Xuefu Road, Nangang District, Harbin, 150086, People’s Republic China

    Rui Zhang & Ye-ping Ren

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  1. Rui Zhang
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  2. Ye-ping Ren
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Correspondence to Ye-ping Ren.

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Zhang, R., Ren, Yp. Protein-energy wasting and peritoneal function in elderly peritoneal dialysis patients. Clin Exp Nephrol 16, 792–798 (2012). https://doi.org/10.1007/s10157-012-0631-5

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  • DOI: https://doi.org/10.1007/s10157-012-0631-5

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