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Comparison of clinical and functional outcome between surgical treatment and carbon ion radiotherapy for pelvic chondrosarcoma

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Abstract

Background

As there are no reports of studies in patients with pelvic chondrosarcoma treated with carbon ion radiotherapy (CIRT), the aim of this study was to evaluate the applicability of CIRT for patients with chondrosarcoma of the pelvis.

Methods

The medical records of 31 patients with chondrosarcoma of the pelvis treated either by surgical resection or by CIRT between 1983 and 2014 were reviewed. There were 22 males and 9 females with a median age of 43 years (range 16–77 years). The median duration of follow-up was 66 months (range 5–289 months). Twenty-four patients underwent surgery, and 7 patients received CIRT (70.4 GyE in 16 fractions over 4 weeks).

Results

The overall local recurrence rate was 32 %, and the estimated overall 5- and 10-year survival rates were 72 and 57 %, respectively. The mean Musculoskeletal Tumor Society functional score was 59 %. The treatment procedures (surgery or CIRT) did not affect overall survival (P = 0.347). However, the patients who underwent surgery had impaired function compared with those who received CIRT (P = 0.03).

Conclusion

Although more patients need to be monitored to assess the clinical and functional outcomes of CIRT for patients with chondrosarcoma of the pelvis, this treatment might offer an acceptable alternative.

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References

  1. Unni KK, Inwards CY (2010) Chondrosarcoma (Primary, Secondary, Dedifferentiated and Clear Cell). In: Dahlin’s bone tumors. 6th edn. Lippincott Williams & Williams, Philadelphia, pp 60–91

  2. Bjornsson J, Mcleod R, Unni K et al (1998) Primary chondrosarcoma of long bones and limb girdles. Cancer 83:2105–2119

    Article  CAS  PubMed  Google Scholar 

  3. Fiorenza F, Abudu A, Grimer R et al (2002) Risk factors for survival and local control in chondrosarcoma of bone. J Bone Joint Surg Br 84-B:93–99

    Article  Google Scholar 

  4. Kamada T, Tsujii H, Tsuji H et al (2002) Efficacy and safety of carbon ion radiotherapy in bone and soft tissue sarcomas. J Clin Oncol 20:4466–4471

    Article  CAS  PubMed  Google Scholar 

  5. Kamada T, Tsujii H, Blakely EA et al (2015) Carbon ion radiotherapy in Japan: an assessment of 20 years of clinical experience. Lancet Oncol 16(2):e93–e100

    Article  PubMed  Google Scholar 

  6. Sugahara S, Kamada T, Imai R et al (2012) Carbon ion radiotherapy for localized primary sarcoma of the extremitied: results of a phase I/II trail. Radiother Oncol 105:226–231

    Article  PubMed  Google Scholar 

  7. Matsumoto K, Imai R, Kamada T et al (2013) Impact of carbon ion radiotherapy for primary spinal sarcoma. Cancer 119:3496–3503

    Article  CAS  PubMed  Google Scholar 

  8. Evans H, Ayala A, Romsdahl M (1977) Prognostic factors in chondrosarcoma of bone. A clinicopathologic analysis with emphasis on histologic grading. Cancer 40:818–831

    Article  CAS  PubMed  Google Scholar 

  9. Enneking W, Dunham W, Florida G (1978) Resection and reconstruction for primary neoplasms involving the innominate bone. J Bone Joint Surg Am 60-A:731–746

    Google Scholar 

  10. O’Connor M, Sim F (1989) Salvage of the limb in the treatment of malignant pelvic tumors. J Bone Joint Surg Am 71-A:481–493

    Google Scholar 

  11. Enneking WF, Spanier SS, Goodman MA (1980) A system for the surgical staging of muscloskeletal sarcoma. Clin Orthop Relat Res 153:106–120

    PubMed  Google Scholar 

  12. Enneking WF, Dunham W, Gebhardt MC et al (1993) A system for the functional evaluation of reconstructive procedures after surgical treatment of tumors of the musculoskeletal system. Clin Orthop Relat Res 286:241–246

    PubMed  Google Scholar 

  13. Steth DS, Yasko AW, Johnson ME et al (1996) Chondrosarcoma of the pelvis; prognostic factors for 67 patients treated with definitive surgery. Cancer 78:745–750

    Article  Google Scholar 

  14. Ozaki T, Hillmann A, Linder N et al (1997) Chondrosarcoma of the pelvis. Clin Orthop Relat Res 337:226–239

    Article  PubMed  Google Scholar 

  15. Wirbel RJ, Schulte M, Maier B et al (2000) Chondrosarcoma of the pelvis: oncologic and functional outcome. Sarcoma 4:161–168

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  16. Pring ME, Weber KL, Unni KK et al (2001) Chondrosarcoma of the pelvis. A review of sixty-four cases. J Bone Joint Surg Am 83-A:1630–1642

    CAS  PubMed  Google Scholar 

  17. Donati D, El Ghoneimy A, Bertoni F et al (2005) Surgical treatment and outcome of conventional pelvic chondrosarcoma. J Bone Joint Surg Br 87:1527–1530

    Article  CAS  PubMed  Google Scholar 

  18. Deloin X, Dumaine V, Biau D et al (2009) Pelvic chondrosarcomas: surgical treatment options. Orthop Traumatol Surg Res 95:393–401

    Article  CAS  PubMed  Google Scholar 

  19. Mavrogenis AF, Angelini A, Drago G et al (2013) Survival analysis of patients with chondrosarcoma of the pelvis. J Surg Oncol 108:19–27

    Article  PubMed  Google Scholar 

  20. Abudu A, Grimer RJ, Cannon SR et al (1997) Reconstruction of the hemipelvis after the excision of malignant tumours. J Bone Joint Surg Br 79-B:773–779

    Article  Google Scholar 

  21. Tujii H, Kamada T (2012) A review of update clinical results of carbon ion radiotherapy. Jpn J Clin Oncol 42(8):670–685

    Article  Google Scholar 

  22. Matsunobu A, Imai R, Kamada T et al (2012) Impact of carbon ion radiotherapy for unresectable osteosarcoma of the trunk. Cancer 118:4555–4563

    Article  PubMed  Google Scholar 

  23. Jaiswal PK, Aston WJ, Grimer RJ et al (2008) Peri-acetabular resection and endoprosthetic reconstruction for tumours of the acetabulum. J Bone Joint Surg Br 90-B:1222–1227

    Article  Google Scholar 

Download references

Conflict of interest

The all authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Musculoskeletal Oncology Service, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1-3-3 Nakamichi, Higashiknari, Osaka, 537-8511, Japan

    Hidetatsu Outani, Kazuya Oshima, Tsukasa Sotobori, Susumu Joyama & Nobuhito Araki

  2. Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, 2-2, Yamada-oka, Suita, Osaka, 565-0871, Japan

    Kenichiro Hamada, Yoshinori Imura, Norifumi Naka & Hideki Yoshikawa

  3. Department of Radiology, Hyogo Ion Beam Medical Center, 1-2-1 Kouto, Shingu-cho, Tatsuno, Hyogo, 679-5165, Japan

    Yusuke Demizu & Tomoaki Okimoto

  4. Department of Orthopaedic Surgery, Osaka National Hospital, 2-1-14 Hoenzaka, Chuo-ku, Osaka, 540-0006, Japan

    Shigeki Kakunaga, Ikuo Kudawara & Takafumi Ueda

  5. Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Anagawa 4-9-1, Inage, Chiba, 263-8555, Japan

    Reiko Imai & Tadashi Kamada

Authors
  1. Hidetatsu Outani
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  2. Kenichiro Hamada
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  3. Yoshinori Imura
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  4. Kazuya Oshima
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  5. Tsukasa Sotobori
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  6. Yusuke Demizu
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  7. Shigeki Kakunaga
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  8. Susumu Joyama
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  9. Reiko Imai
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  10. Tomoaki Okimoto
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  11. Norifumi Naka
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  12. Ikuo Kudawara
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  13. Takafumi Ueda
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  14. Nobuhito Araki
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  15. Tadashi Kamada
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  16. Hideki Yoshikawa
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Corresponding author

Correspondence to Hidetatsu Outani.

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Outani, H., Hamada, K., Imura, Y. et al. Comparison of clinical and functional outcome between surgical treatment and carbon ion radiotherapy for pelvic chondrosarcoma . Int J Clin Oncol 21, 186–193 (2016). https://doi.org/10.1007/s10147-015-0870-z

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  • DOI: https://doi.org/10.1007/s10147-015-0870-z

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