International Journal of Clinical Oncology

, Volume 15, Issue 3, pp 314–318

Ewing’s sarcoma of the kidney

Authors

    • Department of MedicineMedical College of Wisconsin
  • Anushayanthan Alfred
    • Department of MedicineMedical College of Wisconsin
  • Ankit Sakhuja
    • Department of MedicineMedical College of Wisconsin
  • Ryan E. Sells
    • Department of MedicineMedical College of Wisconsin
  • Joseph John Zechlinski
    • Department of MedicineMedical College of Wisconsin
Case Report

DOI: 10.1007/s10147-010-0042-0

Cite this article as:
Angel, J.R., Alfred, A., Sakhuja, A. et al. Int J Clin Oncol (2010) 15: 314. doi:10.1007/s10147-010-0042-0

Abstract

Primitive neuroectodermal tumors (PNETs) are small, round-cell tumors of neural crest origin classically found in the central nervous system (CNS) but more recently characterized in the periphery. Peripherally located PNETs (pPNETs) are members of the Ewing’s sarcoma family of tumors (EFTs). Renal localization of pPNETs is very rare, is found in young adults, and is characterized by an aggressive clinical course and poor prognosis. We present the case of a young man with renal pPNET characterized by psuedorosette formation, cluster of differentiation 99 (CD 99+), focally positive for neuron-specific enolase (NSE), with cytogenetic findings of the translocation t(11;22)(q24;q12) and the unique abnormality of trisomy 7. To our knowledge, we report the first case of trisomy 7 and PNET.

Keywords

Ewing’s sarcomaPrimitive neuroectodermal tumorTranslocationTrisomy

Copyright information

© Japan Society of Clinical Oncology 2010