Risk associated with perioperative red blood cell transfusion in cranial surgery

  • Jonathan A. Cohen
  • Nima Alan
  • Andreea Seicean
  • Robert J. Weil
Original Article

DOI: 10.1007/s10143-017-0819-y

Cite this article as:
Cohen, J.A., Alan, N., Seicean, A. et al. Neurosurg Rev (2017). doi:10.1007/s10143-017-0819-y

Abstract

We assessed the impact of intra- and postoperative RBC transfusion on postoperative morbidity and mortality in cranial surgery. A total of 8924 adult patients who underwent cranial surgery were identified in the 2006–2011 American College of Surgeons (ACS) National Surgical Quality Improvement Program (NSQIP) database. Patients undergoing a biopsy, radiosurgery, or outpatient surgery were excluded. Propensity scores were calculated according to demographic variables, comorbidities, and preoperative laboratory values. Patients who had received RBC transfusion were matched to those who did not, by propensity score, preoperative hematocrit level, and by length of surgery, as an indirect measure of potential intraoperative blood loss. Logistic regression was used to predict adverse postoperative outcomes. A total of 625 (7%) patients were transfused with one or more units of packed RBCs. Upon matching, preoperative hematocrit, length of surgery, and emergency status were no longer different between transfused and non-transfused patients. RBC transfusion was associated with prolonged length of hospitalization (OR 1.6, 95% CI 1.2–2.2), postoperative complications (OR 2.8, 95% CI 2.0–3.8), 30-day return to operation room (OR 2.0, 95% CI 1.3–3.2), and 30-day mortality (OR 4.3, 95% CI 2.4–7.6). RBC transfusion is associated with substantive postoperative morbidity and mortality in patients undergoing both elective and emergency cranial surgery. These results suggest judicious use of transfusion in cranial surgery, consideration of alternative means of blood conservation, or pre-operative restorative strategies in patients undergoing elective surgery, when possible.

Keywords

Transfusion Perioperative Cranial Surgery 

Copyright information

© Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  • Jonathan A. Cohen
    • 1
  • Nima Alan
    • 2
    • 3
  • Andreea Seicean
    • 2
    • 4
    • 5
  • Robert J. Weil
    • 6
    • 7
  1. 1.Department of Neurological SurgeryUniversity of Pittsburgh Medical CenterPittsburghUSA
  2. 2.Case Western Reserve University School of MedicineClevelandUSA
  3. 3.Department of Neurological SurgeryUniversity of Pittsburgh Medical CenterPittsburghUSA
  4. 4.Department of Epidemiology and BiostatisticsCase Western Reserve UniversityClevelandUSA
  5. 5.Department of PsychiatryUniversity of Illinois at ChicagoChicagoUSA
  6. 6.The Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, and Department of Neurosurgery, The Neurological InstituteCleveland ClinicClevelandUSA
  7. 7.Neurosurgery DepartmentGeisinger Health SystemDanvilleUSA