Abstract
The complexation between circular DNA and individual chains of PEO-b-P4VP with a relatively long PEO block and a short P4VP block is highly controllable when the interaction between DNA and the polymer is weak enough. When one circular DNA chain is taken into consideration, and the polymer concentration is far below its critical micelle concentration (CMC), polymer chains are absorbed by DNA chain due to the interaction between the negatively charged DNA chain and the slightly positively charged P4VP block chains. After the adsorption/complexation, the DNA chain is converted into a nanoring (type 1). In the nanoring, the DNA chain is sufficiently wrapped by the polymer and adopts a fully stretched conformation, so that the DNA compact ratio in the nanorings is close to 1. When the polymer concentration is close to but lower than the CMC, the free polymer chains in the solution are adsorbed not only by the DNA chain but also by the polymer chains that have already been adsorbed on the DNA chain. As a result, the circular DNA chain adsorbs more polymer chains, and thus the resultant nanoring (type 2) has a larger width. In the type 2 nanoring, the DNA chain is slightly compressed; the DNA compact ratio is only about 2−3. Therefore, complexation induced by the weak interaction between DNA and PEO-b-P4VP below the CMC can produce narrow-disperse and large nanorings with a perimeter of micrometers, which are difficult to prepare by existing methods.
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Findeis, M.A., "Nonviral vectors for gene therapy: methods and protocols", Springer Science & Business Media, Totowa, New Jersey, 2001
Pack, D.W., Hoffman, A.S., Pun, S. and Stayton, P.S., Nat. Rev. Drug Discov., 2005, 4: 581
Putnam, D., Nat. Mater., 2006, 5: 439
Xia, J.L., Chen, J., Guo, Z.P., Lin, L., Yang, H.Y. and Feng, Z.C., Chinese J. Polym. Sci., 2016, 34: 316
Yin, H., Kanasty, R.L., Eltoukhy, A.A., Vegas, A.J., Dorkin, J.R. and Anderson, D.G., Nat. Rev. Genet., 2014, 15: 541
Hu, X., Li, Y., Liu, T., Zhang, G. and Liu, S., Chem. Asian J., 2014, 9: 2148
Li, J., Ge, Z. and Liu, S., Chem. Commun., 2013, 49: 6974
Cavalieri, F., Postma, A., Lee, L. and Caruso, F., ACS Nano, 2009, 3: 234
Dias, R. and Lindman, B., "DNA interactions with polymers and surfactants", John Wiley & Sons, Hoboken, New Jersey, 2008
Liu, T. and Zhang, Y.F., Chinese J. Polym. Sci., 2013, 31: 924
Roh, Y.H., Ruiz, R.C., Peng, S., Lee, J.B. and Luo, D., Chem. Soc. Rev., 2011, 40: 5730
Seeman, N.C., Nature, 2003, 421: 427
Estévez-Torres, A. and Baigl, D., Soft Matter, 2011, 7: 6746
Fan, Y. and Chen, D., Acta Chimica Sinica (in Chinese), 2014, 72: 1012
Zhou, J.H., Wen, H., Su, C.C. and Niu, L., Chinese J. Polym. Sci., 2014, 32: 1460
Zhou, T., Llizo, A., Wang, C., Xu, G. and Yang, Y., Nanoscale, 2013, 5: 8288
Zhang, K., Jiang, M. and Chen, D., Angew. Chem. Int. Ed., 2012, 51: 8744
Zhang, K., Miao, H. and Chen, D., J. Am. Chem. Soc., 2014, 136: 15933
Miao, H., Li, J. and Chen, D., Soft Matter, 2016, 12: 4590
Sidorov, S.N., Bronstein, L.M., Kabachii, Y.A., Valetsky, P.M., Soo, P.L., Maysinger, D. and Eisenberg, A., Langmuir, 2004, 20: 3543
Xia, J., Zhang, X. and Matyjaszewski, K., Macromolecules, 1999, 32: 3531
Chen, W., Turro, N.J. and Tomalia, D.A., Langmuir, 2000, 16: 15
Dong, Y., Sun, Y., Wang, L., Wang, D., Zhou, T., Yang, Z., Chen, Z., Wang, Q., Fan, Q. and Liu, D., Angew. Chem. Int. Ed., 2014, 53: 2607
Zhao, Z., Chen, C., Dong, Y., Yang, Z., Fan, Q.H. and Liu, D., Angew. Chem. Int. Ed., 2014, 53: 13468
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This work was financially supported by the National Natural Science Foundation of China (Nos. 21334001 and 21574025).
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Miao, H., Wang, Yf., Dong, Hy. et al. Complexation induced by weak interaction between DNA and PEO-b-P4VP below the CMC of the polymer. Chin J Polym Sci 35, 46–53 (2017). https://doi.org/10.1007/s10118-016-1857-6
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DOI: https://doi.org/10.1007/s10118-016-1857-6