Abstract
Effects of low-level laser therapy (442 and 532 nm) and LED radiation (650 nm) on mitochondrial respiration in experimental endotoxic shock have been studied. A model of experimental endotoxic shock in rats was obtained by intraperitoneal injection of lipopolysaccharide B. It was found that low-level laser therapy and LED radiation dramatically affected the rate of mitochondrial respiration in third and fourth states both in LPS-treated animals and in control experiments. The maximal increase of the mitochondrial respiration rate (of about 40 %) in LPS-treated animals was observed when blue laser was applied at the dose of 6 J/cm2. Measurements of inner mitochondrial membrane surface potential with fluorescence probe JC-1 in LPS-treated rats showed in approximately 10 % decrease of potential in LPS-treated animals compared to control.
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This study was supported by the Russian Foundation for Basic Research grant no. 11-04-01455-а.
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Buravlev, E.A., Zhidkova, T.V., Vladimirov, Y.A. et al. Effects of laser and LED radiation on mitochondrial respiration in experimental endotoxic shock. Lasers Med Sci 28, 785–790 (2013). https://doi.org/10.1007/s10103-012-1155-7
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DOI: https://doi.org/10.1007/s10103-012-1155-7