Hematoporphyrin-mediated fluorescence reflectance imaging: application to early tumor detection in vivo in small animals
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- Autiero, M., Cozzolino, R., Laccetti, P. et al. Lasers Med Sci (2009) 24: 284. doi:10.1007/s10103-007-0523-1
The in vivo early detection of subcutaneous human tumors implanted in small animals was studied by laser-induced fluorescence reflectance imaging (FRI), with a hematoporphyrin (HP) compound as an exogenous optical contrast agent. Tumor detection was shown to be possible just 3 days after the inoculation of tumor cells, when tumors were neither visible nor palpable. However, this detection capability is limited to a temporal window of approximately 100 h from HP administration and to a low optical contrast of the tumor (<2).