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Enterobacter cloacae pyomyositis complicating chronic granulomatous disease and review of gram-negative bacilli pyomyositis

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Abstract

Pyomyositis is a primary purulent infection of skeletal muscles mostly described in tropical areas. Staphylococcus aureus is by far the main causative microorganisms. In temperate areas, pyomyositis more frequently affects male adults with immunodeficiency. Gram-negative bacilli pyomyositis are uncommon and occur mainly in this context of immunodeficiency. Only one case of Enterobacter cloacae pyomyositis has been reported so far. Chronic Granulomatous Disease (CGD) is a rare inherited immunodeficiency characterized by a loss of NADPH oxidase activity in phagocytic cells that favors infections due to catalase-positive microorganisms. Pyomyositis has only been described once as a complication of CGD. We report here a case of Enterobacter cloacae-associated pyomyositis of the left thigh in a patient with CGD, and review the literature on Gram-negative pyomyositis.

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Authors and Affiliations

  1. Paris Descartes University, Paris, France

    M. Gousseff, F. Lanternier, O. Chandesris, N. Mahlaoui, O. Hermine, O. Lortholary & M. Lecuit

  2. Department of Infectious Diseases, Necker Pasteur Center for Infectious Diseases, Necker-Enfants Malades University Hospital, 149, rue de Sèvres, 75743, Paris Cedex 15, France

    M. Gousseff, F. Lanternier, O. Lortholary & M. Lecuit

  3. Department of Microbiology, Necker-Enfants Malades University Hospital, 149, rue de Sèvres, 75743, Paris Cedex 15, France

    A. Ferroni

  4. Department of Hematology, Necker-Enfants Malades University Hospital, 149, rue de Sèvres, 75743, Paris Cedex 15, France

    O. Chandesris & O. Hermine

  5. CEREDIH (Centre de Référence Déficits Immunitaires Héréditaires), French National Reference Center for Primary Immune Deficiencies, Necker-Enfants Malades University Hospital, 149, rue de Sèvres, 75743, Paris Cedex 15, France

    F. Lanternier, N. Mahlaoui, O. Hermine, O. Lortholary & M. Lecuit

  6. Paris Descartes University, Sorbonne Paris Cité, Imagine Institute, 149, rue de Sèvres, 75743, Paris Cedex 15, France

    N. Mahlaoui

  7. Paediatric Haematology-Immunology and Rheumatology Unit, Necker-Enfants Malades University Hospital, 149, rue de Sèvres, 75743, Paris Cedex 15, France

    N. Mahlaoui

  8. Institut Pasteur, Inserm U1117, Biology of Infection Unit, Paris, France

    M. Lecuit

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  1. M. Gousseff
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Gousseff, M., Lanternier, F., Ferroni, A. et al. Enterobacter cloacae pyomyositis complicating chronic granulomatous disease and review of gram-negative bacilli pyomyositis. Eur J Clin Microbiol Infect Dis 32, 729–734 (2013). https://doi.org/10.1007/s10096-013-1815-y

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