Abstract
The background of this study is to determine whether there is an association between music intervention and cognitive dysfunction therapy in healthy older adults, and if so, whether music intervention can be used as first-line non-pharmacological treatment. The method used in this study is to conduct a systematic review and meta-analysis of clinical trials that examined the effects of music intervention on patient-relevant and disease-specific outcomes. A comprehensive literature was performed on PubMed, EMbase and the Cochrane Library from inception to September 2016. A total of 10 studies (14 analyses, 966 subjects) were included; all of them had an acceptable quality based on the PEDro scale score and CASP scale score. Compared with control group, the standardized mean difference was 0.03 (−0.18 to 0.24) for cognitive function as primary outcome by random effect model; secondary outcomes were included disruptive behavior, depressive score, anxiety and quality of life. No evidence of publication bias could be found in funnel plots, Begg’s test and Egger’s test. Subgroup analyses showed that intervention method, comparator, trial design, trial period and outcome measure instruments made little difference in outcomes. Meta-regression might not identify cause of heterogeneity. This study is registered with PROSPERO, number CRD442016036264. There was positive evidence to support the use of music intervention on treatment of cognitive function.
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Abbreviations
- CASP:
-
Critical Appraisal Skills Program
- CCT:
-
Controlled clinical trials
- MMSE:
-
Mini-mental state examination
- PEDro:
-
Physiotherapy Evidence Database scale score
- RCT:
-
Randomized controlled trials
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Acknowledgements
We thank the authors of primary studies for providing data and other critical information. And the authors would like to thank all researchers and participants for their valuable contributions to this article. This work was supported by the National Natural Science Foundation of China (ID 81371395), Liaoning Provincial Natural Science Foundation (ID 2015020547), and China Post-doctoral Science Foundation (ID 2015M581375) to Yi Sui.
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Xu, B., Sui, Y., Zhu, C. et al. Music intervention on cognitive dysfunction in healthy older adults: a systematic review and meta-analysis. Neurol Sci 38, 983–992 (2017). https://doi.org/10.1007/s10072-017-2878-9
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DOI: https://doi.org/10.1007/s10072-017-2878-9