Abstract
The pathophysiology of vestibular migraine (VM) is at present poorly understood. Functional magnetic resonance imaging (fMRI), a technique that measures brain activity by detecting changes associated with blood flow oxygenation, has been used to study neural pathways involved in VM pathophysiology. In this study, we summarize results of previous fMRI studies in VM patients, both during and between vertigo attacks. Moreover, we report our experience in two patients with definite VM, who underwent fMRI during a visual stimulation in a vertigo-free period. Compared with 15 matched healthy controls, fMRI demonstrated activation of brain areas related to integration of visual and vestibular cues (increased activation of the paracentral lobule and bilateral inferior parietal lobule and decreased activation of the left superior frontal gyrus, head of the caudate nucleus, left superior temporal gyrus, left parahippocampal gyrus, and right lingual gyrus). Our results partially confirm those of other authors, reporting increased activation of multimodal association brain areas (BA 40, BA 31/5) and decreased activation of occipital regions In addition, we also found a decreased activation of fronto-temporal areas, such as the parahippocampal region, functionally involved in space memory and navigation.
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References
Neuhauser H, Leopold M, von Brevern M, Arnold G, Lempert T (2001) The interrelations of migraine, vertigo and migrainous vertigo. Neurology 56:436–441
Lempert T, Olesen J, Furman J, Waterston J, Seemungal B, Carey J, Bisdorff A, Versino M, Eversian S, Newman-Toker D (2012) Vestibular migraine: diagnostic criteria. J Vestib Res 22:167–172
Von Brevern M, Zeise D, Neuhauser H, Clarke AH, Lempert T (2004) Acute Migrainous vertigo: clinical and oculographic findings. Brain 128:365–374
Russo A, Marcelli V, Esposito F, Corvino V, Marcuccio L, Giannone A, Conforti R, Marciano E, Tedeschi G, Tessitore A (2014) Abnormal thalamic function in patients with vestibular migraine. Neurology 82:2120–2126
Bense S, Stephan T, Yousry TA, Brandt T, Dieterich M (2001) Multisensory cortical signal increases and decreases during vestibular galvanic stimulation (fMRI). J Neurophysiol 85:886–899
Bucher SF, Dieterich M, Wiesmann M et al (1998) Cerebral functional magnetic resonance imaging of vestibular, auditory, and nociceptive areas during galvanic stimulation. Ann Neurol 44:120–125
Bottini G, Karnath HO, Vallar G, Sterzi R, Frith CD, Frackowiak RS et al (2001) Cerebral representation for egocentric space: functional-anatomical evidence from caloric vestibular stimulation and neck vibration. Brain 124:1182–1196
Ventre-Dominey J, Nighoghossian N, Denise P (2003) Evidence for interacting cortical control of vestibular function and spatial representation in man. Neuropsychologia 41:1884–1898
zu Eulemberg P, Stoeter P, Dieterich M (2010) Voxel-based morphometry depicts central compensation after vestibular neuritis. Ann Neurol 68:241–249
Shin JH, Kim YK, Kim HJ, Kim JS (2014) Altered brain metabolism in vestibular migraine: comparison of interictal and ictal findings. Cephalagia 34:58–67
Schwedt TJ, Chiang C, Chong CD, Dodick DW (2015) Functional MRI of migraine. Lancet Neurol 14:81–91
Small DM, Gitelman DR, Gregory MD, Nobre AC, Parrish TB, Mesulam MM (2003) The posterior cingulate and medial prefrontal cortex mediate the anticipatory allocation of spatial attention. Neuroimage 18:633–641
Rushworth MF, Johansen-Berg H, Gobel SM, Devlin JT (2003) The left parietal and premotor cortices: motor attention and selection. Neuroimage 20:89–100
Goldberg I, Harel M, Malach R (2006) When the brain loses its self: prefrontal inactivation during sensorimotor processing. Neuron 50:329–339
Marcus DS, Van Essen DC (2002) Scene segmentation and attention in primate cortical areas V1 and V2. J Neurophysiol 88:2648–2658
Hüfner K, Strupp M, Smith P, Brandt T, Jahn K (2011) Spatial separation of visual and vestibular processing in the human hippocampal formation. Ann N Y Acad Sci 1233:177–186
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Teggi, R., Colombo, B., Rocca, M.A. et al. A review of recent literature on functional MRI and personal experience in two cases of definite vestibular migraine. Neurol Sci 37, 1399–1402 (2016). https://doi.org/10.1007/s10072-016-2618-6
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DOI: https://doi.org/10.1007/s10072-016-2618-6