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Mild encephalitis/encephalopathy with a reversible splenial lesion: five cases and a literature review

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Abstract

The aim of this study was to explore the clinical characteristics and etiology of mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) in China by retrospectively analyzing five MERS cases from the Jiangsu Provincial Hospital within a total of 27 reported MERS cases from available Chinese literature. Most of the 27 cases originated near the eastern and southern parts of China. Ages for 23 MERS cases were under 30 years and the female-to-male ratio was 1:1.25. The major causes of MERS included infection, antiepileptic drug withdrawal, high-altitude cerebral edema, and cesarean section (C-section). Hyponatremia was also observed in 10 MERS cases. All patients had a complete recovery within a month. Steroids and IVIG were the most commonly used therapy for MERS, but their efficiency remained questionable.

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Acknowledgments

This study was supported with Scientific research project of Jiangsu Provincial Health Department, Key subjects of maternal and child health in Jiangsu Province, FXK201212.

Conflict of interest

The authors declare that they have no financial or other conflicts of interest in relation to this research and its publication.

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    Authors and Affiliations

    1. Department of Pediatrics, The First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, China

      Jing Jing Pan, Chao Lu & Yu-hua Hu

    2. Department of Neonatology, Nanjing Children’s Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, China

      You-yan Zhao & Yang Yang

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    1. Jing Jing Pan
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    2. You-yan Zhao
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    3. Chao Lu
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    4. Yu-hua Hu
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    Correspondence to Yu-hua Hu or Yang Yang.

    Additional information

    Jing Jing Pan and You-yan Zhao are co-first authors and contributed equally to this work.

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    Pan, J.J., Zhao, Yy., Lu, C. et al. Mild encephalitis/encephalopathy with a reversible splenial lesion: five cases and a literature review. Neurol Sci 36, 2043–2051 (2015). https://doi.org/10.1007/s10072-015-2302-2

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    • DOI: https://doi.org/10.1007/s10072-015-2302-2

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