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Association of serum levels of intercellular adhesion molecule-1 and interleukin-6 with migraine

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Abstract

To investigate the associations of serum levels of intercellular adhesion molecule-1 (ICAM1) and the pro-inflammatory cytokine interleukin-6 (IL-6) with migraine and migraine subtypes, and to study their correlation with each other in this condition. We used enzyme-linked immunosorbent assay to measure serum levels of ICAM1 and IL-6 in 103 migraine patients with and without aura, in both attack and pain-free periods, and in 100 healthy control subjects. Serum levels of ICAM1 and IL-6 were significantly higher in migraine patients during attacks than in controls (p < 0.05). Serum ICAM1 levels were significantly higher in migraine with aura (MA) than in migraine without aura (MO), (p < 0.05). Correlation analysis indicated a significant positive correlation between serum levels of ICAM1 and IL-6 (p < 0.05) in migraine patients during attacks. Our results indicate that ICAM1 and IL-6 are involved in the pathogenesis of migraine attacks, possibly via an interactive mechanism.

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The authors have no conflict of interest to declare.

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Authors and Affiliations

  1. Department of Neurology, The People’s Hospital of Liaoning Province, No. 33, WenYi Road, Shenhe District, Shenyang, 110016, Liaoning, China

    Fengzhi Wang, Qiu He, Zhanxiu Ren, Hemin Zhang & Guofeng Tai

  2. Department of Neurosurgery, The People’s Hospital of Liaoning Province, No. 33, WenYi Road, Shenhe District, Shenyang, 110016, Liaoning, China

    Fuyong Li

  3. Department of Neurology, The People’s Hospital of Sanya City, Sanya, China

    Wei Chen

  4. Graduate of Neurology of Dalian Medical University, Dalian, China

    Xiang Lin

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  1. Fengzhi Wang
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  2. Qiu He
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  3. Zhanxiu Ren
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  4. Fuyong Li
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  5. Wei Chen
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  7. Hemin Zhang
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  8. Guofeng Tai
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Correspondence to Qiu He.

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Wang, F., He, Q., Ren, Z. et al. Association of serum levels of intercellular adhesion molecule-1 and interleukin-6 with migraine. Neurol Sci 36, 535–540 (2015). https://doi.org/10.1007/s10072-014-2010-3

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  • DOI: https://doi.org/10.1007/s10072-014-2010-3

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