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Inactivition of CDKL3 mildly inhibits proliferation of cells at VZ/SVZ in brain

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Abstract

CDKL3 has an important role in regulating cell growth and/or differentiation, and its inactivation is recently reported to be related to non-syndromic mild mental retardation (MR). MR is a common neurological disorder, predominantly characterized by impaired cognitive function. Though genetic factors play a very important role in the pathogenesis of MR, to date, only few genes linked to MR have been characterized and understood very well. Here, we investigated the role of the CDKL3 in the proliferation of cells surrounding the brain ventricle, and the results showed down-regulating CDKL3 by the method of RNAi in the cells surrounding the brain ventricle of the mouse embryo at E15 may inhibit their proliferation. As our previous study had shown that Cdkl3 mRNA expression is developmentally regulated in the central nervous system, peaking during late embryonic and early postnatal stages which are the key stages of neurite formation and maturation, furtherly, the present findings indicated that CDKL3 may be involved in proliferation of cells surrounding the brain ventricle where neuronal progenitor cells are enriched during the late embryo stage, supporting the notion that CDKL3 inactivation contributes to non-syndromic mild MR.

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Authors and Affiliations

  1. Department of Neurology, The First Hospital Affiliated to Dalian Medical University, 222 Zhongshan Road, Dalian, 116011, China

    Zanhua Liu & Dingbo Tao

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  1. Zanhua Liu
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  2. Dingbo Tao
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Correspondence to Dingbo Tao.

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Liu, Z., Tao, D. Inactivition of CDKL3 mildly inhibits proliferation of cells at VZ/SVZ in brain. Neurol Sci 36, 297–302 (2015). https://doi.org/10.1007/s10072-014-1952-9

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  • DOI: https://doi.org/10.1007/s10072-014-1952-9

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