Neurological Sciences

, Volume 34, Issue 8, pp 1347–1353

White matter hyperintensities and quality of life in acute lacunar stroke

Authors

    • Department of Psychiatry, Chinese University of Hong Kong
  • H. J. Liang
    • Department of Psychiatry, Chinese University of Hong Kong
  • Y. K. Chen
    • Department of Neurology, Dongguan People’s Hospital
  • A. T. Ahuja
    • Department of Imaging and Interventional Radiology, Chinese University of Hong Kong
  • Winnie C. W. Chu
    • Department of Imaging and Interventional Radiology, Chinese University of Hong Kong
  • V. C. T. Mok
    • Department of Medicine and Therapeutics, Chinese University of Hong Kong
  • Gabor S. Ungvari
    • University of Notre Dame/Marian Centre
  • K. S. Wong
    • Department of Medicine and Therapeutics, Chinese University of Hong Kong
Original Article

DOI: 10.1007/s10072-012-1267-7

Cite this article as:
Tang, W.K., Liang, H.J., Chen, Y.K. et al. Neurol Sci (2013) 34: 1347. doi:10.1007/s10072-012-1267-7

Abstract

White matter hyperintensities (WMH) are common in stroke. The influence of WMH on health-related quality of life (HRQoL) following a lacunar stroke is unknown. This study evaluated the impact of WMH on HRQoL in acute lacunar stroke. A cohort of 160 patients with acute lacunar stroke admitted to the stroke unit of a university-affiliated regional hospital in Hong Kong was recruited. Three months after the index stroke, a research assistant administered the Short Form-36 (SF-36) to assess HRQoL. The severity of WMH was evaluated with magnetic resonance imaging (MRI). In univariate analysis, the severity of deep WMH (DWMH) negatively correlated with patients’ vitality (VT; p < 0.05), social function (SF; p < 0.001), role-emotional (RE; p < 0.01), mental health (MH; p < 0.01), and mental component summary (MCS; p < 0.001) scores of HRQoL. DWMH was independently associated with all of the above five SF-36 scores (p < 0.05) in linear regression analysis. These findings suggest that DWMH has a significant impact on the HRQoL of stroke survivors. The importance of DWMH in the long-term HRQoL in lacunar stroke warrants further investigation.

Keywords

Quality of lifeLacunar strokeWhite matter hyperintensitiesMRI

Copyright information

© Springer-Verlag Italia 2012