Neurological Sciences

, Volume 34, Issue 8, pp 1347–1353

White matter hyperintensities and quality of life in acute lacunar stroke

  • W. K. Tang
  • H. J. Liang
  • Y. K. Chen
  • A. T. Ahuja
  • Winnie C. W. Chu
  • V. C. T. Mok
  • Gabor S. Ungvari
  • K. S. Wong
Original Article

DOI: 10.1007/s10072-012-1267-7

Cite this article as:
Tang, W.K., Liang, H.J., Chen, Y.K. et al. Neurol Sci (2013) 34: 1347. doi:10.1007/s10072-012-1267-7

Abstract

White matter hyperintensities (WMH) are common in stroke. The influence of WMH on health-related quality of life (HRQoL) following a lacunar stroke is unknown. This study evaluated the impact of WMH on HRQoL in acute lacunar stroke. A cohort of 160 patients with acute lacunar stroke admitted to the stroke unit of a university-affiliated regional hospital in Hong Kong was recruited. Three months after the index stroke, a research assistant administered the Short Form-36 (SF-36) to assess HRQoL. The severity of WMH was evaluated with magnetic resonance imaging (MRI). In univariate analysis, the severity of deep WMH (DWMH) negatively correlated with patients’ vitality (VT; p < 0.05), social function (SF; p < 0.001), role-emotional (RE; p < 0.01), mental health (MH; p < 0.01), and mental component summary (MCS; p < 0.001) scores of HRQoL. DWMH was independently associated with all of the above five SF-36 scores (p < 0.05) in linear regression analysis. These findings suggest that DWMH has a significant impact on the HRQoL of stroke survivors. The importance of DWMH in the long-term HRQoL in lacunar stroke warrants further investigation.

Keywords

Quality of lifeLacunar strokeWhite matter hyperintensitiesMRI

Copyright information

© Springer-Verlag Italia 2012

Authors and Affiliations

  • W. K. Tang
    • 1
  • H. J. Liang
    • 1
  • Y. K. Chen
    • 2
  • A. T. Ahuja
    • 3
  • Winnie C. W. Chu
    • 3
  • V. C. T. Mok
    • 4
  • Gabor S. Ungvari
    • 5
  • K. S. Wong
    • 4
  1. 1.Department of Psychiatry, Chinese University of Hong KongHong Kong SARChina
  2. 2.Department of Neurology, Dongguan People’s HospitalDongguanChina
  3. 3.Department of Imaging and Interventional Radiology, Chinese University of Hong KongHong Kong SARChina
  4. 4.Department of Medicine and Therapeutics, Chinese University of Hong KongHong Kong SARChina
  5. 5.University of Notre Dame/Marian CentrePerthAustralia