Original Article

Neurological Sciences

, Volume 34, Issue 5, pp 683-687

First online:

Validation of the Italian version of the Movement Disorder Society—Unified Parkinson’s Disease Rating Scale

  • Angelo AntoniniAffiliated withDepartment for Parkinson’s disease, IRCCS San Camillo Email author 
  • , Giovanni AbbruzzeseAffiliated withDepartment of Neurosciences, Ophthalmology and Genetics, Centre for Movement Disorders, University of Genoa
  • , Luigi Ferini-StrambiAffiliated withUniversità Vita-Salute San Raffaele
  • , Barbara TilleyAffiliated withUniversity of Texas Health Science Center School of Public Health at Houston
  • , Jing HuangAffiliated withUniversity of Texas Health Science Center School of Public Health at Houston
  • , Glenn T. StebbinsAffiliated withDepartment of Neurological Services, Rush University Medical Center
  • , Christopher G. GoetzAffiliated withDepartment of Neurological Services, Rush University Medical Center
  • , Paolo BaroneAffiliated withNeurodegenerative Diseases Center, University of Salerno, Salerno, and IDC-Hermitage-Capodimonte
  • , MDS-UPDRS Italian Validation Study Group
    • , Monica Bandettini di Poggio
    • , Giovanni Fabbrini
    • , Flavio Di Stasio
    • , Michele Tinazzi
    • , Tommaso Bovi
    • , Silvia Ramat
    • , Sara Meoni
    • , Gianni Pezzoli
    • , Margherita Canesi
    • , Paolo Martinelli
    • , Cesa Lorella Maria Scaglione
    • , Aroldo Rossi
    • , Nicola Tambasco
    • , Gabriella Santangelo
    • , Marina Picillo
    • , Letterio Morgante
    • , Francesca Morgante
    • , Rocco Quatrale
    • , MariaChiara Sensi
    • , Manuela Pilleri
    • , Roberta Biundo
    • , Giampietro Nordera
    • , Antonella Caria
    • , Claudio Pacchetti
    • , Roberta Zangaglia
    • , Leonardo Lopiano
    • , Maurizio Zibetti
    • , Mario Zappia
    • , Alessandra Nicoletti
    • , Aldo Quattrone
    • , Maria Salsone
    • , Gianni Cossu
    • , Daniela Murgia
    • , Alberto Albanese
    • , Francesca Del Sorbo

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access


The Movement Disorder Society-sponsored revision of the Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) has been available in English since 2008. As part of this process, the MDS-UPDRS organizing team developed guidelines for development of official non-English translations. We present here the formal process for completing officially approved non-English versions of the MDS-UPDRS and specifically focus on the first of these versions in Italian. The MDS-UPDRS was translated into Italian and tested in 377 native-Italian speaking PD patients. Confirmatory and exploratory factor analyses determined whether the factor structure for the English-language MDS-UPDRS could be confirmed in data collected using the Italian translation. To be designated an ‘Official MDS translation,’ the Comparative Fit Index (CFI) had to be ≥0.90 relative to the English-language version. For all four parts of the Italian MDS-UPDRS, the CFI, in comparison with the English-language data, was ≥0.94. Exploratory factor analyses revealed some differences between the two datasets, however these differences were considered to be within an acceptable range. The Italian version of the MDS-UPDRS reaches the criterion to be designated as an Official Translation and is now available for use. This protocol will serve as outline for further validation of this in multiple languages.


Parkinson’s disease MDS-UPDRS Unified Parkinson’s Disease Rating Scale Rating scales