Neurological Sciences

, Volume 27, Supplement 2, pp s86–s90

From spreading depression to the trigeminovascular system


  • T. Dalkara
    • Department of NeurologyFaculty of Medicine, Hacettepe University
  • N. T. Zervas
    • Department of NeurosurgeryMassachusetts General Hospital, Harvard Medical School
    • Department of RadiologyMassachusetts General Hospital

DOI: 10.1007/s10072-006-0577-z

Cite this article as:
Dalkara, T., Zervas, N.T. & Moskowitz, M.A. Neurol Sci (2006) 27: s86. doi:10.1007/s10072-006-0577-z


Migraine headaches have a complex pathophysiology; both vascular and neuronal mechanisms have been proposed. One possible scenario begins with brain-initiated events evolving to cortical spreading depression (CSD), which in turn activates the trigeminal nerve to cause headaches. Experimental evidence supports a relationship between CSD as a cause of migraine aura as well as CSD as a cause of trigeminal activation. Susceptibility to CSD and to migraine appears to be genetically determined. In some migraine subtypes, genes controlling translocation of calcium, sodium and potassium have been implicated, perhaps altering the susceptibility to CSD. This chapter briefly reviews current knowledge pertaining to migraine pathophysiology with emphasis on current notions linking disturbances in ion flux to the genesis of headache.

Key words

MigrainePhysiopathologyTrigeminal nerveNeurogenic inflammationSpreading depression

Copyright information

© Springer-Verlag Italia 2006