Neurological Sciences

, Volume 26, Issue 6, pp 456-459

First online:

Acute myocardial infarction after sumatriptan administration for cluster headache

  • E. AnghileriAffiliated withU.O.C. di Neurologia, Ospedale S. Bortolo
  • , V. TosoAffiliated withU.O.C. di Neurologia, Ospedale S. Bortolo
  • , F. PeriniAffiliated withU.O.C. di Neurologia, Ospedale Vittorio Emanuele III

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The pain of cluster headache attacks is severe, excruciating and selectively responsive to subcutaneous sumatriptan. Serious cardiovascular events attributed to sumatriptan are extremely rare and have most often been reported in patients at significant cardiovascular risk, or in overt cardiovascular disease. They also have occurred, however, in patients without evidence of cardiovascular disease. We describe a 42-year-old man with episodic cluster headache without history of coronary artery disease who was admitted to our coronary care unit for acute myocardial infarction after 3 h of subcutaneous injection of sumatriptan. During hospitalisation cluster headache attacks were successfully treated with e.v. indomethacin.

Key words

Episodic cluster headache Sumatriptan Indomethacin Parecoxib