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Are obesity, ACPAs and periodontitis conditions that influence the risk of developing rheumatoid arthritis in first-degree relatives?

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Abstract

The aim of this study was to investigate the body mass index (BMI), anti-citrullinated protein antibodies (ACPAs) status and the presence of periodontitis and IgG-1/IgG-2 antibodies against Porphyromonas gingivalis (Pg) in the first-degree relatives (FDRs) of rheumatoid arthritis (RA) patients and compare these variables with a control group of healthy individuals from the general population. In total, 100 FDR individuals and 200 healthy controls matched by age and gender were included. Rheumatologic and periodontal assessment was performed, and the presence of ACPAs and anti-P. gingivalis antibodies was evaluated. Groupwise comparisons were analysed using the McNemar and Wilcoxon tests. A conditional logistic regression analysis was performed to establish the associations between BMI, ACPAs and periodontitis in both groups. In the FDR group, 70% of the subjects were female, with a mean age of 37.3 ± 13 years. Obesity was observed in 17 and 7% of the FDRs and controls, respectively. ACPAs were found in 7% of the FDRs vs. 2.5% of the controls. Periodontitis was diagnosed in 79 and 56% of the FDRs and controls, respectively. Among the FDRs, 15% had severe periodontitis. There were associations in the FDR group related to the presence of obesity (OR 2.93, 95% CI 1.03–8.28), ACPAs (OR 2.45, 95% CI 0.7–8.32) and periodontitis (OR 3.70 95% CI 1.89–7.29). Regarding anti-P. gingivalis antibodies and smoking history, no differences were found between the groups. Obesity, ACPAs and periodontitis (diagnosis and severity) can be considered as relevant conditions associated with the development of RA in FDRs.

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Acknowledgements

This study was supported by the Universidad El Bosque (PCI 2013-469), the Hospital Militar Central (2013-048), and the Government Institute of Science, Technology, and Innovation, Francisco Jose de Caldas—COLCIENCIAS (Grant No. 130854531734-2011 and 130865740792).

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Authors and Affiliations

  1. Unit of Oral Basic Investigation, School of Dentistry, Universidad El Bosque, Av. Cra 9 # 131A 02, Bogotá, Colombia

    Sonia Unriza-Puin, Wilson Bautista-Molano, Gloria I Lafaurie, Lorena Chila-Moreno & Consuelo Romero-Sánchez

  2. School of Medicine, Universidad Militar Nueva Granada, Cra 5 # 49 00, Third Floor, Bogotá, Colombia

    Wilson Bautista-Molano, Juan Manuel Bello-Gualtero & Consuelo Romero-Sánchez

  3. Rheumatology Department, Hospital Militar Central, Cra. 5 # 49 00, Bogotá, Colombia

    Rafael Valle-Oñate, Juan Manuel Bello-Gualtero & Consuelo Romero-Sánchez

  4. Fundación Instituto de Reumatología Fernando Chalem, Calle 73 # 20A 21, Bogotá, Colombia

    Philippe Chalem

Authors
  1. Sonia Unriza-Puin
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  2. Wilson Bautista-Molano
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  3. Gloria I Lafaurie
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  4. Rafael Valle-Oñate
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  5. Philippe Chalem
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  6. Lorena Chila-Moreno
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  7. Juan Manuel Bello-Gualtero
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  8. Consuelo Romero-Sánchez
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Correspondence to Sonia Unriza-Puin.

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The study subjects provided written informed consent. The institutional ethics committee approved the study: Universidad El Bosque (PCI 2014-469) and Hospital Militar Central (2013-048).

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Unriza-Puin, S., Bautista-Molano, W., Lafaurie, G.I. et al. Are obesity, ACPAs and periodontitis conditions that influence the risk of developing rheumatoid arthritis in first-degree relatives?. Clin Rheumatol 36, 799–806 (2017). https://doi.org/10.1007/s10067-016-3519-z

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  • DOI: https://doi.org/10.1007/s10067-016-3519-z

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