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Clinical and immunogenetic characterization in psoriatic arthritis patients

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Abstract

In psoriatic arthritis (PsA), genetic factors play a substantial role in disease susceptibility as well as in its expression. This study aims to determine the distribution of class I and class II HLA antigens in PsA patients and secondly to analyze the influence of genetic factors in the clinical expression of the disease. Consecutive PsA patients (CASPAR criteria) with less than 1 year of disease duration were included. Sociodemographic and clinical data were recorded. Blood samples were obtained, DNA was extracted by polymerase chain reaction (PCR), and class I (A, B, and C) and class II (DR) HLA antigens were determined by oligotyping. A control group of 100 nonrelated healthy controls from the general population served as control. p values were corrected (pc) according to the number of alleles tested. A total of 73 patients were included, 37 were females (50.7 %) with a median disease duration of 72 months (interquartile range (IQR) 24–149). Thirty-three patients (45.2 %) had a family history of psoriasis. When analyzing all the class I and class II HLA antigens, a significantly higher frequency of B38 (odds ratio (OR) 2.95, p = 0.03) and Cw6 (OR 2.78, p = 0.009) was found in PsA patients compared to the control group. On the contrary, the HLA-A11 (OR 0.14, p = 0.04) and B7 (OR 0.31, p = 0.03) were significantly more frequent among healthy controls. Furthermore, B18 was significantly more frequent in patients with early arthritis onset (less than 40 years): seven patients (22.6 %) with early onset compared to two patients (4.8 %) with late onset (p = 0.03). No association between HLA-B27 and spondylitis or HLA-DR4 with polyarticular involvement was observed. The HLA-B38 and Cw6 alleles are associated with a greater PsA susceptibility in Argentine population.

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The authors declare no conflicts of interest.

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Authors and Affiliations

  1. Section of Rheumatology, Instituto de Rehabilitación Psicofísica, Echeverría 955, 1428, Buenos Aires, Argentina

    Emilce Edith Schneeberger, Gustavo Citera, Gustavo Rodríguez Gil, Gabriel Marcos Rosemffet & José Antonio Maldonado Cocco

  2. Hospital San Martín, HIGA, La Plata, Argentina

    Amelia Granel & Alfredo Arturi

  3. Centro Médico Privado de Reumatología, San Miguel de Tucumán, Argentina

    Alberto Berman & Alberto Spindler

  4. INCUCAI – Instituto Nacional Central Unico Coordinador de Ablación e Implante, Buenos Aires, Argentina

    Victor Hugo Morales

Authors
  1. Emilce Edith Schneeberger
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  2. Gustavo Citera
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  3. Gustavo Rodríguez Gil
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  4. Amelia Granel
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  5. Alfredo Arturi
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  6. Gabriel Marcos Rosemffet
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  7. José Antonio Maldonado Cocco
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  8. Alberto Berman
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  9. Alberto Spindler
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  10. Victor Hugo Morales
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Correspondence to Gustavo Citera.

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Schneeberger, E.E., Citera, G., Rodríguez Gil, G. et al. Clinical and immunogenetic characterization in psoriatic arthritis patients. Clin Rheumatol 34, 1413–1418 (2015). https://doi.org/10.1007/s10067-014-2739-3

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  • DOI: https://doi.org/10.1007/s10067-014-2739-3

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