Abstract
Eltrombopag is a new thrombomimetic medication approved for the treatment of immune thrombocytopenia. There are very few reports on the use of eltrombopag in patients with thrombocytopenia associated with sytemic lupus.We present a recent case of a patient with lupus with severe thrombocytopenia refractory to conventional therapy and full recovery with the use of eltrombopag. The present status of the literature with the use of this medication in patients with lupus is reviewed and discussed.
Similar content being viewed by others
References
Bashal F (2013) Hematological disorders in patients with systemic lupus erythematosus. Open Rheumatol J 7:87–95
Provan D, Stasi R, Newland AC et al (2010) International consensus report on the investigation and management of primary immune thrombocytopenia. Blood 115:168–186
Keeling DM, Isenberg DA (1993) Haematological manifestations of systemic lupus erythematosus. Blood Rev 7:199–207
Hallam S, Provan D, Newland AC (2013) Immune thrombocytopenia—what are the new treatment options? Expert Opin Biol Ther 13:1173–1185
Imbach P, Crowther M (2011) Thrombopoietin-receptor agonists for primary immune thrombocytopenia. N Engl J Med 365:734–741
Alkaabi JK, Alkindi S, Riyami NA et al (2012) Successful treatment of severe thrombocytopenia with romiplostim in a pregnant patient with systemic lupus erythematosus. Lupus 21:1571–1574
Cela I, Miller IJ, Katz RS et al (2010) Successful treatment of amegakaryocytic thrombocytopenia with eltrombopag in a patient with systemic lupus erythematosus (SLE). Clin Adv Hematol Oncol 8:806–809
Kuter DJ, Begley CG (2002) Recombinant human thrombopoietin: basic biology and evaluation of clinical studies. Blood 100:3457–3469
Olnes MJ, Scheinberg P, Calvo KR et al (2012) Eltrombopag and improved hematopoiesis in refractory aplastic anemia. N Engl J Med 367:11–19
Kremer J, Li ZG, Hall S et al (2013) Tofacitinib in combination with nonbiologic disease-modifying antirheumatic drugs in patients with active rheumatoid arthritis: a randomized trial. Ann Intern Med 159:253–261
Li J, Yang C, Xia Y et al (2001) Thrombocytopenia caused by the development of antibodies to thrombopoietin. Blood 98:3241–3248
Cheng G, Saleh MN, Marcher C et al (2011) Eltrombopag for management of chronic immune thrombocytopenia (RAISE): a 6-month, randomised, phase 3 study. Lancet 377:393–402
Bussel JB, Cheng G, Saleh MN et al (2007) Eltrombopag for the treatment of chronic idiopathic thrombocytopenic purpura. N Engl J Med 357:2237–2247
Saleh MN, Bussel JB, Cheng G et al (2013) Safety and efficacy of eltrombopag for treatment of chronic immune thrombocytopenia: results of the long-term, open-label EXTEND study. Blood 121:537–545
Kuter DJ, Bussel JB, Newland A et al (2013) Long-term treatment with romiplostim in patients with chronic immune thrombocytopenia: safety and efficacy. Br J Haematol 161:411–423
Kuter DJ, Rummel M, Boccia R et al (2010) Romiplostim or standard of care in patients with immune thrombocytopenia. N Engl J Med 363:1889–1899
Bussel JB, Kuter DJ, George JN et al (2006) AMG 531, a thrombopoiesis-stimulating protein, for chronic ITP. N Engl J Med 355:1672–1681
Fain O, Ebbo M, Khellaf M et al (2013) Prolonged remission after TPO-receptor agonist discontinuation in adults with chronic ITP. Results of a French Observational Study. Blood 122:327
Qin P, Qiu J, Shao L et al (2013) Sustained complete remission of corticosteroid-resistant immune thrombocytopenia with a short course of recombinant human thrombopoietin. Blood 122:4746
Desmond R, Townsley DM, Dumitriu B, et al (2014) Eltrombopag restores tri-lineage hematopoiesis in refractory severe aplastic anemia which can be sustained on discontinuation of drug. Blood 123:1818
Disclosures
None.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Scheinberg, P., Singulane, C.C., Barbosa, L.S.G. et al. Successful platelet count recovery in lupus-associated thrombocytopenia with the thrombopoietin agonist eltrombopag. Clin Rheumatol 33, 1347–1349 (2014). https://doi.org/10.1007/s10067-014-2600-8
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10067-014-2600-8