Clinical Rheumatology

, Volume 29, Issue 12, pp 1353–1356

QT dispersion in uncomplicated familial Mediterranean fever

  • Naomi Nussinovitch
  • Avi Livneh
  • Keren Katz
  • Pnina Langevitz
  • Olga Feld
  • Moshe Nussinovitch
  • Benjamin Volovitz
  • Merav Lidar
  • Udi Nussinovitch
Original Article

DOI: 10.1007/s10067-010-1434-2

Cite this article as:
Nussinovitch, N., Livneh, A., Katz, K. et al. Clin Rheumatol (2010) 29: 1353. doi:10.1007/s10067-010-1434-2

Abstract

The aim of the study was to further evaluate repolarization dispersion in familial Mediterranean fever (FMF). Findings on 12-lead electrocardiography were compared with 32 patients with uncomplicated FMF and age- and sex-matched control subjects. All procedures followed stringent standards. Repolarization and dispersion parameters were computed with designated computer software, and results of the five beats were subsequently averaged. There were no statistically significant differences between the groups in average QT and average corrected QT interval length, average QT interval dispersion, average QT corrected dispersion, or QT dispersion ratio. During 6 months of follow-up, no cases of sudden death or arrhythmia were documented in either group. Patients with FMF who are continuously treated with low-dose colchicine and have not developed amyloidosis seem to have QT dispersion parameters similar to those of healthy subjects and therefore apparently have no increased risk of adverse cardiac events associated with abnormal repolarization.

Keywords

ArrhythmiaAtherosclerosisFamilial Mediterranean feverQT dispersion (QTd)

Abbreviations

FMF

familial Mediterranean fever

QTd

QT interval dispersion

QTc

corrected QT

QTcd

QT corrected dispersion

QTdr

QT dispersion ratio

Copyright information

© Clinical Rheumatology 2010

Authors and Affiliations

  • Naomi Nussinovitch
    • 1
    • 2
  • Avi Livneh
    • 2
    • 3
  • Keren Katz
    • 2
  • Pnina Langevitz
    • 2
    • 3
  • Olga Feld
    • 2
    • 3
  • Moshe Nussinovitch
    • 2
    • 4
  • Benjamin Volovitz
    • 2
    • 4
  • Merav Lidar
    • 2
    • 3
  • Udi Nussinovitch
    • 2
    • 5
  1. 1.Hypertension Unit and Department of Internal Medicine DSheba Medical CenterTel HashomerIsrael
  2. 2.Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael
  3. 3.The Heller Institute of Medical Research, and Department of Medicine FSheba Medical CenterTel HashomerIsrael
  4. 4.Department of Pediatrics CSchneider Children’s Medical Center of IsraelPetach TikvaIsrael
  5. 5.Department of Internal Medicine BSheba Medical CenterTel HashomerIsrael