Clinical Rheumatology

, Volume 25, Issue 6, pp 773-777

First online:

TNF-receptor-associated periodic syndrome (TRAPS): an autosomal dominant multisystem disorder

  • Nima RezaeiAffiliated withImmunology, Asthma and Allergy Research Institute, Tehran University of Medical SciencesDivision of Genomic Medicine, The University of SheffieldImmunology, Asthma and Allergy Research Institute, Children Medical Center Email author 

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The TNF-receptor-associated periodic sydrome (TRAPS) is an autosomal dominant auto-inflammatory disorder, characterized by recurrent febrile attacks and localized inflammation. TRAPS is caused by mutations in the gene encoding the TNF Receptor Super Family 1A (TNFRSF1A) on chromosome 12p13. However, the incomplete penetrance and genetic heterogeneity have been reported in this syndrome. Although the ethnic diversity and clinical heterogeneity may propose the role of other genes in the pathogenesis of TRAPS, some low-penetrance TNFRSF1A variants contribute to atypical inflammatory responses in other autoimmune diseases. Furthermore, molecular studies on TRAPS and other auto-inflammatory disorders could be suggested to identify additional genes coding the molecules in the TNF signalling process.


Hereditary periodic fever syndromes Mutation Penetrance TNFRSF1A (Tumor necrosis factor receptor superfamily, member 1A)