Molecules and Cells

, Volume 34, Issue 6, pp 509–516

Impact of retrotransposons in pluripotent stem cells

Authors

  • Yoshiaki Tanaka
    • Department of Genetics, Yale Stem Cell CenterYale School of Medicine
  • Leeyup Chung
    • Department of PediatricsDuke University Medical Center
    • Department of Genetics, Yale Stem Cell CenterYale School of Medicine
Minireview

DOI: 10.1007/s10059-012-0242-8

Cite this article as:
Tanaka, Y., Chung, L. & Park, I. Mol Cells (2012) 34: 509. doi:10.1007/s10059-012-0242-8

Abstract

Retrotransposons, which constitute approximately 40% of the human genome, have the capacity to ‘jump’ across the genome. Their mobility contributes to oncogenesis, evolution, and genomic plasticity of the host genome. Induced pluripotent stem cells as well as embryonic stem cells are more susceptible than differentiated cells to genomic aberrations including insertion, deletion and duplication. Recent studies have revealed specific behaviors of retrotransposons in pluripotent cells. Here, we review recent progress in understanding retrotransposons and provide a perspective on the relationship between retrotransposons and genomic variation in pluripotent stem cells.

Keywords

Alu L1 LTR retrotransposon pluripotent stem cell SVA

Copyright information

© The Korean Society for Molecular and Cellular Biology and Springer Netherlands 2012